Effectiveness of secondary prevention in metalworkers with work-related skin diseases and comparison with participants of a tertiary prevention program: A prospective cohort study.
Adult
Dermatitis, Atopic
/ prevention & control
Dermatitis, Occupational
/ prevention & control
Female
Filaggrin Proteins
Germany
Hand Dermatoses
/ prevention & control
Humans
Male
Metallurgy
Metals
/ adverse effects
Middle Aged
Prospective Studies
Risk Assessment
Secondary Prevention
/ methods
Tertiary Prevention
/ methods
contact dermatitis
filaggrin
hand eczema
health education
metalworker
occupational
prevention
tobacco
work-related
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
30
05
2020
revised:
28
07
2020
accepted:
30
07
2020
pubmed:
4
8
2020
medline:
7
8
2021
entrez:
4
8
2020
Statut:
ppublish
Résumé
In Germany, a multistep approach has been established to prevent work-related skin diseases (WRSDs). To evaluate the effect of a secondary individual prevention program (SIP) in metalworkers with WRSD and to compare their characteristics with those of participants of a tertiary individual prevention program (TIP). In a prospective cohort study, metalworkers with WRSD of the hands participating either in the SIP (n = 114) or in the TIP (n = 83) were recruited. At baseline and at the respective follow-up 8-12 weeks after the SIP or at dismissal from the TIP (3-4 weeks later), questionnaires were completed and the severity of WRSD was assessed. Saliva samples were collected for assessment of filaggrin (FLG) mutations and an explorative genome-wide association study (GWAS). Ninety-three SIP patients (81.6%) attended the follow-up. Disease severity was significantly reduced, and knowledge and protective behavior were significantly improved compared to baseline. Significant differences between SIP and TIP patients were found regarding duration and severity of symptoms, work absenteeism, tobacco smoking, and presence of atopic dermatitis, but not regarding FLG mutations and by GWAS. The SIP was effective in metalworkers with WRSDs. Individual factors may influence the course of the disease and the need for the TIP.
Sections du résumé
BACKGROUND
BACKGROUND
In Germany, a multistep approach has been established to prevent work-related skin diseases (WRSDs).
OBJECTIVES
OBJECTIVE
To evaluate the effect of a secondary individual prevention program (SIP) in metalworkers with WRSD and to compare their characteristics with those of participants of a tertiary individual prevention program (TIP).
PATIENTS AND METHODS
METHODS
In a prospective cohort study, metalworkers with WRSD of the hands participating either in the SIP (n = 114) or in the TIP (n = 83) were recruited. At baseline and at the respective follow-up 8-12 weeks after the SIP or at dismissal from the TIP (3-4 weeks later), questionnaires were completed and the severity of WRSD was assessed. Saliva samples were collected for assessment of filaggrin (FLG) mutations and an explorative genome-wide association study (GWAS).
RESULTS
RESULTS
Ninety-three SIP patients (81.6%) attended the follow-up. Disease severity was significantly reduced, and knowledge and protective behavior were significantly improved compared to baseline. Significant differences between SIP and TIP patients were found regarding duration and severity of symptoms, work absenteeism, tobacco smoking, and presence of atopic dermatitis, but not regarding FLG mutations and by GWAS.
CONCLUSIONS
CONCLUSIONS
The SIP was effective in metalworkers with WRSDs. Individual factors may influence the course of the disease and the need for the TIP.
Substances chimiques
FLG protein, human
0
Filaggrin Proteins
0
Metals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
497-506Subventions
Organisme : The study was funded by the Volkswagen Foundation (Niedersächsisches Vorab ZN2778).
Informations de copyright
© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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