Disease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States.
biologic therapy
ileal pouch-anal anastomosis
pouchitis
Journal
Crohn's & colitis 360
ISSN: 2631-827X
Titre abrégé: Crohns Colitis 360
Pays: England
ID NLM: 101752188
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
11
03
2020
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
4
8
2020
Statut:
ppublish
Résumé
Gaps exist in our understanding of the clinical course of pouch-related disorders. We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.
Sections du résumé
BACKGROUND
BACKGROUND
Gaps exist in our understanding of the clinical course of pouch-related disorders.
METHODS
METHODS
We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch.
RESULTS
RESULTS
Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery.
CONCLUSIONS
CONCLUSIONS
Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.
Identifiants
pubmed: 32744536
doi: 10.1093/crocol/otaa039
pii: otaa039
pmc: PMC7380550
doi:
Types de publication
Journal Article
Langues
eng
Pagination
otaa039Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.
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