COVID-19, Virology and Geroscience: A Perspective.


Journal

The journal of nutrition, health & aging
ISSN: 1760-4788
Titre abrégé: J Nutr Health Aging
Pays: France
ID NLM: 100893366

Informations de publication

Date de publication:
2020
Historique:
entrez: 4 8 2020
pubmed: 4 8 2020
medline: 11 8 2020
Statut: ppublish

Résumé

A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019. The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease 2019 (COVID-19). Older adults have higher peak of viral load and, especially those with comorbidities, had higher COVID-19-related fatality rates than younger adults. In this Perspective paper, we summarize current knowledge about SARS-CoV-2 and aging, in order to understand why older people are more affected by COVID-19. We discuss about the possibility that the so-called "immunosenescence" and "inflammaging" processes, already present in a fraction of frail older adults, could allow the immune escape of SARS-CoV-2 leading to COVID-19 serious complications. Finally, we propose to use geroscience approaches to the field of COVID-19.

Identifiants

pubmed: 32744561
doi: 10.1007/s12603-020-1416-2
pmc: PMC7301052
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

685-691

Déclaration de conflit d'intérêts

The authors declare no conflict of interest

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Auteurs

C Vellas (C)

Camille Vellas, INSERM UMR1043 - CNRS UMR5282 Centre de Physiopathologie Toulouse-Purpan (CPTP), Toulouse, France, vellas.camille@gmail.com.

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Classifications MeSH