Exosome-mediated human norovirus infection.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
05
2020
accepted:
17
07
2020
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV infection. HuNoV is contained within stool-derived exosomes, and exosome-associated HuNoV has been shown to replicate in human intestinal enteroids. In this study, we examine exosome-associated HuNoV infection of Vero cells and show that exosomes containing HuNoV may attach, infect, and be passaged in Vero cells. These findings support earlier findings and have implications for developing HuNoV disease intervention strategies.
Identifiants
pubmed: 32745122
doi: 10.1371/journal.pone.0237044
pii: PONE-D-20-12799
pmc: PMC7398508
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0237044Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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