Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis.
Animals
Disease Models, Animal
Disease Progression
Encephalomyelitis, Autoimmune, Experimental
/ genetics
Female
Gene Expression
/ genetics
Gene Expression Profiling
/ methods
Humans
Immunotherapy
/ methods
Mice, Inbred Strains
Monitoring, Physiologic
/ methods
Multiple Sclerosis
/ genetics
Recurrence
Treatment Outcome
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 08 2020
03 08 2020
Historique:
received:
16
09
2019
accepted:
09
07
2020
entrez:
5
8
2020
pubmed:
5
8
2020
medline:
9
9
2020
Statut:
epublish
Résumé
Relapses in multiple sclerosis can result in irreversible nervous system tissue injury. If these events could be detected early, targeted immunotherapy could potentially slow disease progression. We describe the use of engineered biomaterial-based immunological niches amenable to biopsy to provide insights into the phenotype of innate immune cells that control disease activity in a mouse model of multiple sclerosis. Differential gene expression in cells from these niches allow monitoring of disease dynamics and gauging the effectiveness of treatment. A proactive treatment regimen, given in response to signal within the niche but before symptoms appeared, substantially reduced disease. This technology offers a new approach to monitor organ-specific autoimmunity, and represents a platform to analyze immune dysfunction within otherwise inaccessible target tissues.
Identifiants
pubmed: 32747712
doi: 10.1038/s41467-020-17629-z
pii: 10.1038/s41467-020-17629-z
pmc: PMC7398910
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3871Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB013198
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243916
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099334
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121462
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148076
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI147677
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDCR NIH HHS
ID : T32 DE007057
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142059
Pays : United States
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