Changes in Histophysiology of the Adrenal Medulla in Rats after Prenatal and Postnatal Exposure to Endocrine Disruptor DDT.
DDT
catecholamines
endocrine disruptor
epinephrine
tyrosine hydroxylase
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
11
12
2019
pubmed:
5
8
2020
medline:
8
6
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
We studied histophysiology of the adrenal medulla in adult (70-day-old) male Wistar rats developmentally exposed to low doses of endocrine disruptor DDT. It was found that exposure to DDT during the prenatal and postnatal ontogeny decelerated the development of the adrenal medulla and reduced the synthesis of tyrosine hydroxylase, the rate-liming enzyme of catecholamine synthesis, in chromaffin cells, which led to a decrease in epinephrine secretion into the blood.
Identifiants
pubmed: 32748142
doi: 10.1007/s10517-020-04895-6
pii: 10.1007/s10517-020-04895-6
doi:
Substances chimiques
Catecholamines
0
Endocrine Disruptors
0
DDT
CIW5S16655
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM