White matter correlates of slowed information processing speed in unimpaired multiple sclerosis patients with young age onset.
Cognitive impairment
Diffusion tensor imaging
Pediatric-onset multiple sclerosis
Processing speed
White matter
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
5
8
2020
medline:
21
7
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
Slowed information processing speed is among the earliest markers of cognitive impairment in multiple sclerosis (MS) and has been associated with white matter (WM) structural integrity. Localization of WM tracts associated with slowing, but not significant impairment, on specific cognitive tasks in pediatric and young age onset MS can facilitate early and effective therapeutic intervention. Diffusion tensor imaging data were collected on 25 MS patients and 24 controls who also underwent the Symbol Digit Modalities Test (SDMT) and the computer-based Cogstate simple and choice reaction time tests. Fractional anisotropy (FA), mean (MD), radial (RD) and axial (AD) diffusivities were correlated voxel-wise with processing speed measures. All DTI metrics of several white matter tracts were significantly different between groups (p < 0.05). Notably, higher MD, RD, and AD, but not FA, in the corpus callosum correlated with lower scores on both SDMT and simple reaction time. Additionally, all diffusivity metrics in the left corticospinal tract correlated negatively with SDMT scores, whereas only MD in the right superior fronto-occipital fasciculus correlated with simple reaction time. In conclusion, subtle slowing of processing speed is correlated with WM damage in the visual-motor processing pathways in patients with young age of MS onset.
Identifiants
pubmed: 32748319
doi: 10.1007/s11682-020-00345-z
pii: 10.1007/s11682-020-00345-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1460-1468Subventions
Organisme : NIH HHS
ID : UL1 TR000002
Pays : United States
Organisme : NIH HHS
ID : R01NS071463
Pays : United States
Organisme : National Multiple Sclerosis Society
ID : 10020073405
Organisme : NIH HHS
ID : UL1 TR000002
Pays : United States
Organisme : NIH HHS
ID : R01NS071463
Pays : United States
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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