Joint effect of tobacco, alcohol, and oral HPV infection on head and neck cancer risk in the French West Indies.
Adult
Aged
Alcohol Drinking
/ adverse effects
Case-Control Studies
Female
Head and Neck Neoplasms
/ diagnosis
Humans
Male
Middle Aged
Papillomavirus Infections
/ diagnosis
Risk Assessment
Risk Factors
Squamous Cell Carcinoma of Head and Neck
/ diagnosis
Tobacco Smoking
/ adverse effects
West Indies
/ epidemiology
French West Indies
alcohol drinking
head and neck cancer
high-risk oral HPV
tobacco smoking
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
16
04
2020
revised:
01
07
2020
accepted:
03
07
2020
pubmed:
5
8
2020
medline:
21
7
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
We investigated the role of tobacco and alcohol consumption on the occurrence of head and neck squamous cell carcinomas (HNSCC), and the joint effects of these factors with oral human papillomavirus (HPV) infection in the French West Indies, in the Caribbean. We conducted a population-based case-control study (145 cases and 405 controls). We used logistic regression models to estimate adjusted odds ratios (OR) and their 95% confidence intervals (CI). Two-way interactions were assessed on both multiplicative and additive scales. Current smoking (OR = 11.6, 95% CI = 6.7-20.1), drinking more than five glasses of alcohol per day (OR = 2.7, 95% CI = 1.2-4.7), and oral infection with High-risk HPV (OR = 2.4, 95% CI = 1.1-5.0) were significantly associated with HNSCC. The combined exposure to tobacco and alcohol produced a significant synergistic effect on the incidence of HNSCC. Oral infection with High-risk HPV increased the risk of HNSCC in never smokers and nondrinkers. The effects of tobacco, alcohol, and of the combined exposure of tobacco and alcohol were substantially lower in HPV-positive than in HPV-negative HNSCC. This is the first case-control study to investigate the role of tobacco smoking, alcohol drinking and oral HPV infection in an Afro-Caribbean population. Although each of these risk factors has a significant effect, our findings indicate that tobacco and alcohol play a less important role in Hr-HPV-positive HNSCC. Further investigations are warranted notably on the interaction of these three risk factors by cancer site.
Identifiants
pubmed: 32750236
doi: 10.1002/cam4.3327
pmc: PMC7520253
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6854-6863Informations de copyright
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
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