Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction.
blood brain barrier
blood retinal barrier
dysfunction
hyperhomocysteinemia
mechanisms
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
29 07 2020
29 07 2020
Historique:
received:
20
06
2020
revised:
24
07
2020
accepted:
27
07
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
10
3
2021
Statut:
epublish
Résumé
Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has been linked to different systemic and neurological diseases, well-known as a risk factor for systemic atherosclerosis and cardiovascular disease (CVD) and has been identified as a risk factor for several ocular disorders, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Different mechanisms have been proposed to explain HHcy-induced visual dysfunction, including oxidative stress, upregulation of inflammatory mediators, retinal ganglion cell apoptosis, and extracellular matrix remodeling. Our previous studies using in vivo and in vitro models of HHcy have demonstrated that Hcy impairs the function of both inner and outer blood retinal barrier (BRB). Dysfunction of BRB is a hallmark of vision loss in DR and AMD. Our findings highlighted oxidative stress, ER stress, inflammation, and epigenetic modifications as possible mechanisms of HHcy-induced BRB dysfunction. In addition, we recently reported HHcy-induced brain inflammation as a mechanism of blood-brain barrier (BBB) dysfunction and pathogenesis of Alzheimer's disease (AD). Moreover, we are currently investigating the activation of glutamate receptor
Identifiants
pubmed: 32751132
pii: biom10081119
doi: 10.3390/biom10081119
pmc: PMC7463551
pii:
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY031631
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029751
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY030054
Pays : United States
Organisme : American Heart Association
ID : 16SDG3070001
Pays : International
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