Circulating Exosomes Inhibit B Cell Proliferation and Activity.
B cells
Bruton’s tyrosine kinase
Head and Neck Cancer
exosomes
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Jul 2020
29 Jul 2020
Historique:
received:
23
06
2020
revised:
19
07
2020
accepted:
24
07
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
6
8
2020
Statut:
epublish
Résumé
(1) Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by a distinctive suppression of the anti-tumor immunity, both locally in the tumor microenvironment (TME) and the periphery. Tumor-derived exosomes mediate this immune suppression by directly suppressing T effector function and by inducing differentiation of regulatory T cells. However, little is known about the effects of exosomes on B cells. (2) Methods: Peripheral B cells from healthy donors and HNSCC patients were isolated and checkpoint receptor expression was analyzed by flow cytometry. Circulating exosomes were isolated from the plasma of HNSCC patients (
Identifiants
pubmed: 32751214
pii: cancers12082110
doi: 10.3390/cancers12082110
pmc: PMC7464446
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHU 2536/3
Organisme : Deutsche Forschungsgemeinschaft
ID : TH 2172/2-1
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