Stable Formulations of Peptide-Based Nanogels.
diagnostic imaging
doxorubicin
hydrogel nanoparticles
inverse emulsion
nanogel formulation
peptide aggregates
peptide-based nanogels
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Jul 2020
29 Jul 2020
Historique:
received:
22
06
2020
revised:
24
07
2020
accepted:
27
07
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
6
3
2021
Statut:
epublish
Résumé
Recently, nanogels have been identified as innovative formulations for enlarging the application of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are HGs-based aggregates with sizes in the range of nanometers and formulated in order to obtain injectable preparations. Regardless of the advantages offered by peptides in a hydrogel preparation, until now, only a few examples of peptide-based nanogels (PBNs) have been developed. Here, we describe the preparation of stable PBNs based on Fmoc-Phe-Phe-OH using three different methods, namely water/oil emulsion (W/O), top-down, and nanogelling in water. The effect of the hydrophilic-lipophilic balance (HLB) in the formulation was also evaluated in terms of size and stability. The resulting nanogels were found to encapsulate the anticancer drug doxorubicin, chosen as the model drug, with a drug loading comparable with those of the liposomes.
Identifiants
pubmed: 32751321
pii: molecules25153455
doi: 10.3390/molecules25153455
pmc: PMC7435922
pii:
doi:
Substances chimiques
Drug Carriers
0
Emulsions
0
Nanogels
0
Peptides
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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