Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.
11β-hydroxylase
adrenocortical carcinomas
adrenocortical tumors
differential diagnosis
steroidogenic enzymes
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
30 Jul 2020
30 Jul 2020
Historique:
received:
16
06
2020
revised:
24
07
2020
accepted:
28
07
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
6
8
2020
Statut:
epublish
Résumé
Autonomous steroid secretion is a common feature of adrenocortical carcinomas (ACC), although not always clinically evident owing to inefficient steroidogenesis with increased release of steroid precursors. Our study aim was to analyze the expression profile of four key proteins involved in the steroidogenesis cascade, in different adrenocortical tumors. Expression of proteins involved in steroidogenesis, namely steroidogenic acute regulatory protein (StAR), 11β-hydroxylase (CYP11B1), aldosterone synthase (CYP11B2) and 17α-hydroxylase (CYP17A1), were analyzed by immunohistochemistry in ACC (
Identifiants
pubmed: 32751564
pii: biomedicines8080256
doi: 10.3390/biomedicines8080256
pmc: PMC7460193
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/MEC-ONC/31384/2017
Organisme : Fundação para a Ciência e a Tecnologia
ID : UID/ Multi/00215/2019
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