Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA
Animals
Anticonvulsants
/ chemistry
Benzodiazepines
/ metabolism
Binding Sites
Cell Line, Tumor
Diazepam
/ metabolism
Fatty Acid Binding Protein 3
/ metabolism
Flumazenil
/ metabolism
Ligands
Male
Mice, Inbred ICR
Pentylenetetrazole
/ metabolism
Receptors, GABA-A
/ metabolism
Seizures
/ drug therapy
Status Epilepticus
/ drug therapy
GABAA receptor
anti-epileptic effect
benzodiazepine recognition site
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Aug 2020
01 Aug 2020
Historique:
received:
14
07
2020
revised:
29
07
2020
accepted:
29
07
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Recently, we developed the fatty acid-binding protein 3 (FABP3) ligand MF1 (4-(2-(1-(2-chlorophenyl)-5-phenyl-1H-pyrazol-3-yl)phenoxy) butanoic acid) as a therapeutic candidate for α-synucleinopathies. MF1 shows affinity towards γ-aminobutyric acid type-A (GABA
Identifiants
pubmed: 32752296
pii: ijms21155525
doi: 10.3390/ijms21155525
pmc: PMC7432285
pii:
doi:
Substances chimiques
Anticonvulsants
0
Fatty Acid Binding Protein 3
0
Ligands
0
Receptors, GABA-A
0
Benzodiazepines
12794-10-4
Flumazenil
40P7XK9392
Diazepam
Q3JTX2Q7TU
Pentylenetetrazole
WM5Z385K7T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Front Neurosci. 2016 Jun 09;10:269
pubmed: 27375426
Tohoku J Exp Med. 2008 Mar;214(3):213-20
pubmed: 18323691
J Alzheimers Dis. 2015;49(3):733-41
pubmed: 26484922
Brain. 2020 May 21;:
pubmed: 32437558
Int J Mol Sci. 2019 Oct 28;20(21):
pubmed: 31661838
Neuropharmacology. 2017 May 1;117:1-13
pubmed: 28093211
Biochim Biophys Acta. 1998 Apr 22;1391(3):287-306
pubmed: 9555061
Mol Psychiatry. 2020 May 6;:
pubmed: 32376999
J Neurosci. 2018 Dec 5;38(49):10411-10423
pubmed: 30341178
Drug Des Devel Ther. 2014 Nov 07;8:2263-71
pubmed: 25422586
Neurosci Lett. 2012 Aug 15;523(2):115-8
pubmed: 22750154
Pharmaceuticals (Basel). 2020 Mar 10;13(3):
pubmed: 32164340
Pharmacotherapy. 2013 Mar;33(3):330-43
pubmed: 23400943
J Pharmacol Sci. 2013;121(1):84-7
pubmed: 23257655
Neurochem Res. 2017 Jul;42(7):1873-1888
pubmed: 28290134
Bioorg Med Chem Lett. 2013 Mar 15;23(6):1662-6
pubmed: 23395658
Int J Mol Sci. 2020 Mar 23;21(6):
pubmed: 32210174
Eur J Pharmacol. 1984 Mar 2;98(3-4):337-45
pubmed: 6327331
Acta Neurol Scand. 2008 Aug;118(2):69-86
pubmed: 18384456
J Chem Neuroanat. 1996 Dec;12(2):113-22
pubmed: 9115666
Cold Spring Harb Perspect Med. 2016 May 02;6(5):
pubmed: 26801895
Brain Res. 2019 Mar 15;1707:190-197
pubmed: 30496735
J Alzheimers Dis. 2017;60(1):211-223
pubmed: 28826176
J Biol Chem. 2014 Jul 4;289(27):18957-65
pubmed: 24855640
Neuropharmacology. 2019 May 15;150:164-174
pubmed: 30930168
Curr Top Med Chem. 2005;5(1):3-14
pubmed: 15638774
Sci Rep. 2017 Apr 24;7:46654
pubmed: 28436443
Alzheimers Dement. 2020 Jun 16;:
pubmed: 32543726
Epilepsy Res. 1993 Feb;14(2):139-48
pubmed: 8095893
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):105-13
pubmed: 14687864
N Engl J Med. 1998 Apr 2;338(14):970-6
pubmed: 9521986
Eur J Pharmacol. 2014 Feb 5;724:152-60
pubmed: 24374009
Alzheimers Res Ther. 2017 Jul 28;9(1):52
pubmed: 28750675
Ann N Y Acad Sci. 1999 Apr 30;868:645-53
pubmed: 10414349
Br Med J. 1967 Jul 8;3(5557):85-8
pubmed: 4961468
Annu Rev Pharmacol Toxicol. 2014;54:483-507
pubmed: 24160694
Mol Neurobiol. 2018 Apr;55(4):3577-3591
pubmed: 28516430
Brain Res Bull. 2020 Jul;160:107-120
pubmed: 32380189
Br J Pharmacol. 1997 Jul;121(6):1171-9
pubmed: 9249254
Eur J Neurosci. 2000 Jul;12(7):2205-10
pubmed: 10947798
Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94
pubmed: 4110397
Neuron. 2007 Dec 6;56(5):763-70
pubmed: 18054854
Epilepsy Res. 2002 Apr;49(2):109-20
pubmed: 12049799
Neurosci Res. 2001 Dec;41(4):397-9
pubmed: 11755227
Epilepsia. 1999;40 Suppl 1:S9-20; discussion S21-2
pubmed: 10421557
Neuron. 2003 May 8;38(3):433-45
pubmed: 12741990
Trends Pharmacol Sci. 2000 Jan;21(1):16-9
pubmed: 10637650