The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
Adult
Alzheimer Disease
/ metabolism
Amyloid beta-Peptides
/ metabolism
Animals
Blood Platelets
/ cytology
Cells, Cultured
Fibrinogen
/ metabolism
Humans
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Peptide Fragments
/ metabolism
Platelet Aggregation
Platelet Glycoprotein GPIIb-IIIa Complex
/ metabolism
Platelet Membrane Glycoproteins
/ genetics
Protein Aggregation, Pathological
/ metabolism
Protein Binding
Receptors, Collagen
/ genetics
Signal Transduction
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
04 08 2020
04 08 2020
Historique:
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
3
11
2021
Statut:
epublish
Résumé
Cerebral amyloid angiopathy (CAA) and β-amyloid (Aβ) deposition in the brain parenchyma are hallmarks of Alzheimer's disease (AD). We previously reported that platelets contribute to Aβ aggregation in cerebral vessels by secreting the factor clusterin upon binding of Aβ40 to the fibrinogen receptor integrin α
Identifiants
pubmed: 32753479
pii: 13/643/eaba9872
doi: 10.1126/scisignal.aba9872
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Platelet Glycoprotein GPIIb-IIIa Complex
0
Platelet Membrane Glycoproteins
0
Receptors, Collagen
0
amyloid beta-protein (1-40)
0
platelet membrane glycoprotein VI
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : CH/03/003/15571
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/16/53/32242
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.