Diclofenac Inhibits Phorbol Ester-Induced Gene Expression and Production of MUC5AC Mucin via Affecting Degradation of IkBα and Translocation of NF-kB p65 in NCI-H292 Cells.
Diclofenac
MUC5AC
Pulmonary mucin
Journal
Biomolecules & therapeutics
ISSN: 1976-9148
Titre abrégé: Biomol Ther (Seoul)
Pays: Korea (South)
ID NLM: 101472832
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
20
05
2020
revised:
13
07
2020
accepted:
13
07
2020
pubmed:
6
8
2020
medline:
6
8
2020
entrez:
6
8
2020
Statut:
ppublish
Résumé
In this study, diclofenac, a non-steroidal anti-inflammatory drug, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. The human respiratory epithelial NCI-H292 cells were pretreated with diclofenac for 30 min and stimulated with phorbol 12-myristate 13-acetate (PMA), for the following 24 h. The effect of diclofenac on PMA-induced nuclear factor kappa B (NF-kB) signaling pathway was also investigated. Diclofenac suppressed the production and gene expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa Bα (IkBα) and NF-kB p65 nuclear translocation. These results suggest diclofenac regulates the gene expression and production of mucin through regulation of NF-kB signaling pathway, in human airway epithelial cells.
Identifiants
pubmed: 32753566
pii: biomolther.2020.090
doi: 10.4062/biomolther.2020.090
pmc: PMC7457166
doi:
Types de publication
Journal Article
Langues
eng
Pagination
431-436Références
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