The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis.
Animals
Antiviral Agents
/ immunology
Betacoronavirus
/ physiology
COVID-19
Cilia
/ drug effects
Coronavirus Infections
/ drug therapy
Dietary Supplements
Homeostasis
/ immunology
Humans
Pandemics
/ prevention & control
Pneumonia, Viral
/ drug therapy
Respiratory Mucosa
/ immunology
SARS-CoV-2
Virus Internalization
/ drug effects
Virus Replication
/ drug effects
Zinc
/ deficiency
2019-nCoV
COVID-19
SARS-CoV2
coronaviridae
impaired immune system
zinc
zinc deficiency
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
Historique:
received:
18
05
2020
accepted:
26
06
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
22
8
2020
Statut:
epublish
Résumé
During the current corona pandemic, new therapeutic options against this viral disease are urgently desired. Due to the rapid spread and immense number of affected individuals worldwide, cost-effective, globally available, and safe options with minimal side effects and simple application are extremely warranted. This review will therefore discuss the potential of zinc as preventive and therapeutic agent alone or in combination with other strategies, as zinc meets all the above described criteria. While a variety of data on the association of the individual zinc status with viral and respiratory tract infections are available, study evidence regarding COVID-19 is so far missing but can be assumed as was indicated by others and is detailed in this perspective, focusing on re-balancing of the immune response by zinc supplementation. Especially, the role of zinc in viral-induced vascular complications has barely been discussed, so far. Interestingly, most of the risk groups described for COVID-19 are at the same time groups that were associated with zinc deficiency. As zinc is essential to preserve natural tissue barriers such as the respiratory epithelium, preventing pathogen entry, for a balanced function of the immune system and the redox system, zinc deficiency can probably be added to the factors predisposing individuals to infection and detrimental progression of COVID-19. Finally, due to its direct antiviral properties, it can be assumed that zinc administration is beneficial for most of the population, especially those with suboptimal zinc status.
Identifiants
pubmed: 32754164
doi: 10.3389/fimmu.2020.01712
pmc: PMC7365891
doi:
Substances chimiques
Antiviral Agents
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1712Informations de copyright
Copyright © 2020 Wessels, Rolles and Rink.
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