A Long Non-coding RNA,
hepatic glycogen storage
insulin resistance
long non-coding RNA
metabolism
regulatory mechanisms
type 2 diabetes
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
12
2019
accepted:
20
05
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
6
8
2020
Statut:
epublish
Résumé
Causal transcripts at genomic loci associated with type 2 diabetes (T2D) are mostly unknown. The chr8p23.1 variant rs4841132, associated with an insulin-resistant diabetes risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene, We tested our hypothesis using Stellaris fluorescent We found that siRNA knockdown decreased We show that the lncRNA
Identifiants
pubmed: 32754192
doi: 10.3389/fgene.2020.00615
pmc: PMC7367044
doi:
Types de publication
Journal Article
Langues
eng
Pagination
615Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK114551
Pays : United States
Organisme : NIDDK NIH HHS
ID : L30 DK106874
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK078616
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK078616
Pays : United States
Informations de copyright
Copyright © 2020 Manning, Goustin, Kleinbrink, Thepsuwan, Cai, Ju, Leong, Udler, Brown, Goodarzi, Rotter, Sladek, Meigs and Lipovich.
Références
PLoS One. 2019 Jan 10;14(1):e0210114
pubmed: 30629617
PLoS Genet. 2011 Mar;7(3):e1001324
pubmed: 21423719
Nature. 2016 Aug 4;536(7614):41-47
pubmed: 27398621
Atherosclerosis. 2013 May;228(1):175-80
pubmed: 23477746
J Biol Chem. 2000 Aug 25;275(34):26396-403
pubmed: 10862764
PLoS Genet. 2012;8(8):e1002907
pubmed: 22916037
Nat Genet. 2018 Nov;50(11):1505-1513
pubmed: 30297969
PLoS One. 2015 Mar 13;10(3):e0118859
pubmed: 25768928
Hepatol Commun. 2018 Apr 25;2(6):666-675
pubmed: 29881818
Hepatology. 2018 Jun;67(6):2182-2195
pubmed: 29266543
Nat Rev Mol Cell Biol. 2006 Nov;7(11):867-73
pubmed: 17057754
Nature. 2014 Mar 27;507(7493):462-70
pubmed: 24670764
J Cell Biol. 1996 Mar;132(6):1133-49
pubmed: 8601590
Circ Cardiovasc Genet. 2016 Jun;9(3):223-30
pubmed: 27071970
Diabetes. 2015 Nov;64(11):3951-62
pubmed: 26159176
Front Genet. 2013 Sep 26;4:183
pubmed: 24133500
Science. 2005 Sep 2;309(5740):1564-6
pubmed: 16141073
Nat Genet. 2012 May 13;44(6):659-69
pubmed: 22581228
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Cell. 2010 Oct 1;143(1):46-58
pubmed: 20887892
Am J Hum Genet. 2018 Mar 01;102(3):375-400
pubmed: 29455858
Am J Epidemiol. 1981 Feb;113(2):144-56
pubmed: 7468572
Nat Genet. 2014 Feb;46(2):136-143
pubmed: 24413736
Curr Cardiovasc Risk Rep. 2014 Jan 1;8(1):368
pubmed: 24729826
BMC Med Genet. 2008 May 22;9:45
pubmed: 18498634
Curr Pharm Des. 2016;22(37):5730-5737
pubmed: 27356775
Nat Commun. 2015 Jan 29;6:5897
pubmed: 25631608
Cell Metab. 2012 Oct 3;16(4):435-48
pubmed: 23040067
Am J Hum Genet. 2016 Jul 7;99(1):56-75
pubmed: 27321945
Nat Genet. 2013 Nov;45(11):1274-1283
pubmed: 24097068
J Hum Genet. 2006;51(12):1087-1099
pubmed: 17066261
Mol Aspects Med. 2015 Dec;46:34-45
pubmed: 26519772
Front Genet. 2018 Nov 06;9:524
pubmed: 30459811
PLoS Genet. 2015 Dec 01;11(12):e1005694
pubmed: 26624892
Ann Hum Genet. 2006 Sep;70(Pt 5):587-93
pubmed: 16907705
Diabetes Care. 2006 Sep;29(9):2114-6
pubmed: 16936162
Nat Commun. 2018 Apr 17;9(1):1512
pubmed: 29666371
Genome Biol. 2010;11(10):R106
pubmed: 20979621
Hum Mol Genet. 2017 May 15;26(10):1966-1978
pubmed: 28334935
Anal Biochem. 1996 May 1;236(2):296-301
pubmed: 8660508
PLoS One. 2018 Jun 18;13(6):e0198166
pubmed: 29912962
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2301-2306
pubmed: 28193859
Cell Metab. 2017 Feb 7;25(2):400-411
pubmed: 28041957
Nature. 2010 Aug 5;466(7307):707-13
pubmed: 20686565
Biostatistics. 2013 Apr;14(2):232-43
pubmed: 23001152
Nat Genet. 2018 Apr;50(4):559-571
pubmed: 29632382
Diabetes. 2013 Sep;62(9):3282-91
pubmed: 23903356
Genes Dev. 2016 Mar 1;30(5):502-7
pubmed: 26944677
Diabetes. 2017 Sep;66(9):2521-2530
pubmed: 28684635
J Biol Chem. 2002 Jan 11;277(2):1524-30
pubmed: 11707447
Am J Hum Genet. 2018 Apr 5;102(4):620-635
pubmed: 29625024
Nat Commun. 2016 Jun 29;7:11764
pubmed: 27353450
Nat Commun. 2016 Aug 19;7:12429
pubmed: 27539542
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
Diabetes. 2000 Dec;49(12):1967-77
pubmed: 11117996
Mol Biosyst. 2016 Feb;12(2):477-9
pubmed: 26661513
PLoS Genet. 2011 Feb 10;7(2):e1001300
pubmed: 21347282
FEBS Lett. 1995 Nov 20;375(3):294-8
pubmed: 7498521
PLoS Genet. 2006 Apr;2(4):e47
pubmed: 16683030
N Engl J Med. 2019 Jan 3;380(1):57-70
pubmed: 30601736
Diabet Med. 2016 Jul;33(7):968-75
pubmed: 26433129
J Hum Genet. 2017 Jan;62(1):97-104
pubmed: 27305986