Erythropoietin receptor in B cells plays a role in bone remodeling in mice.
Pro-B cells
bone marrow
cFMS/CD115/CSF1R
erythropoietin
lymphocytes
osteoclastogenesis
transdifferentiation
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
03
2020
accepted:
02
06
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
20
5
2021
Statut:
epublish
Résumé
Erythropoietin (EPO) is a key regulator of erythropoiesis. However, EPO receptors (EPO-Rs) are also expressed on non-erythroid cell types, including myeloid and bone cells. Immune cells also participate in bone homeostasis. B cells produce receptor activator of nuclear factor kappa-Β ligand (RANKL) and osteoprotegerin (OPG), two pivotal regulators of bone metabolism. Here we explored the ability of B cells to transdifferentiate into functional osteoclasts and examined the role of EPO in this process in a murine model.
Identifiants
pubmed: 32754275
doi: 10.7150/thno.45845
pii: thnov10p8744
pmc: PMC7392011
doi:
Substances chimiques
RANK Ligand
0
Receptors, Erythropoietin
0
Tnfsf11 protein, mouse
0
Erythropoietin
11096-26-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8744-8756Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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