Study of occupational exposure to brick kiln emissions on heavy metal burden, biochemical profile, cortisol level and reproductive health risks among female workers at Rawat, Pakistan.
Antioxidants
BMI
Brick kilns
Cortisol
Heavy metals
Lipid profile
Public health
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
06
03
2020
accepted:
27
07
2020
pubmed:
6
8
2020
medline:
26
11
2020
entrez:
6
8
2020
Statut:
ppublish
Résumé
The present study was planned to understand the heavy metal burden and its possible actions in blood of occupational females working at brick kilns at Rawat, Pakistan. A total of 232 women were included in the study, of which 114 presented control subjects. Apart from collection of demographic data, fertility indicators and body mass index (BMI), blood was collected from subjects that was later used for the determination of heavy metal concentrations using atomic absorption spectroscopy and haematological profile. Blood was centrifuged and plasma was obtained and stored at - 20° to study biochemical variables (sodium dismutase, peroxidase, reactive oxygen species, thiobarbituric acid reactive species, protein estimation), lipid profile and cortisol concentrations among the two groups. Analysis of heavy metal in blood showed elevated levels of cadmium (3.09 ± 0.01 μg/dl), chromium (4.20 ± 0.02 μg/dl) and nickel (5.59 ± 0.03 μg/dl) in worker's group as compared with control. Increased platelet count; decreased antioxidant enzyme and increased oxidants level; increased total cholesterol, low-density lipoprotein (LDL) and triglyceride (TG); decreased total protein and high-density lipoprotein (HDL); and increased cortisol levels were evident among workers as compared with the control group. The study concluded that occupational workers experience increased heavy metals burden in blood and, therefore, pose a risk to human health by causing reduction in antioxidant enzymes concentration and increase in stress conditions.
Identifiants
pubmed: 32754884
doi: 10.1007/s11356-020-10275-4
pii: 10.1007/s11356-020-10275-4
doi:
Substances chimiques
Metals, Heavy
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44073-44088Références
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