Melatonin alters neuronal architecture and increases cysteine-rich protein 1 signaling in the male mouse hippocampus.
Animals
Avoidance Learning
/ drug effects
CA1 Region, Hippocampal
/ drug effects
Dendrites
/ drug effects
Dendritic Spines
/ drug effects
Dentate Gyrus
/ drug effects
Hippocampus
/ drug effects
LIM Domain Proteins
/ drug effects
Male
Melatonin
/ pharmacology
Mice
Mice, Inbred C57BL
Neurites
/ drug effects
Neuronal Plasticity
/ drug effects
Neurons
/ drug effects
Nuclear Proteins
/ drug effects
Signal Transduction
/ drug effects
cysteine-rich protein 1
dendritic complexity
hippocampal neuron
melatonin
structural plasticity
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
24
02
2020
revised:
13
07
2020
accepted:
19
07
2020
pubmed:
6
8
2020
medline:
30
10
2021
entrez:
6
8
2020
Statut:
ppublish
Résumé
Neuronal plasticity describes changes in structure, function, and connections of neurons. The hippocampus, in particular, has been shown to exhibit considerable plasticity regarding both physiological and morphological functions. Melatonin, a hormone released by the pineal gland, promotes cell survival and dendrite maturation of neurons in the newborn brain and protects against neurological disorders. In this study, we investigated the effect of exogenous melatonin on neuronal architecture and its possible mechanism in the hippocampus of adult male C57BL/6 mice. Melatonin treatment significantly increased the total length and complexity of dendrites in the apical and basal cornu ammonis (CA) 1 and in the dentate gyrus in mouse hippocampi. Spine density in CA1 apical dendrites was increased, but no significant differences in other subregions were observed. In primary cultured hippocampal neurons, the length and arborization of neurites were significantly augmented by melatonin treatment. Additionally, western blot and immunohistochemical analyses in both in vivo and in vitro systems revealed significant increases in the level of cysteine-rich protein 1 (crp-1) protein, which is known to be involved in dendritic branching in mouse hippocampal neurons after melatonin treatment. Our results suggest that exogenous melatonin leads to significant alterations of neuronal micromorphometry in the adult hippocampus, possibly via crp-1 signaling.
Substances chimiques
Csrp1 protein, mouse
0
LIM Domain Proteins
0
Nuclear Proteins
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2333-2348Informations de copyright
© 2020 Wiley Periodicals LLC.
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