Interleukin 35 Regulatory B Cells.
Animals
B-Lymphocyte Subsets
/ immunology
B-Lymphocytes, Regulatory
/ immunology
Cell Plasticity
/ immunology
Cytokines
/ genetics
Disease Management
Disease Susceptibility
Humans
Immune System Diseases
/ diagnosis
Immunomodulation
Immunotherapy
Interleukins
/ metabolism
Signal Transduction
/ drug effects
T-Lymphocytes
/ immunology
Breg immunotherapy
interleukin 10
interleukin 35
interleukin-35-producing Breg (i35-Breg)
regulatory B cell (Breg)
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
16
06
2020
revised:
17
07
2020
accepted:
21
07
2020
pubmed:
7
8
2020
medline:
1
5
2021
entrez:
7
8
2020
Statut:
ppublish
Résumé
B lymphocytes play a central role in host immunity. They orchestrate humoral immune responses that modulate activities of other immune cells and produce neutralizing antibodies that confer lasting immunity to infectious diseases including smallpox, measles and poliomyelitis. In addition to these traditional functions is the recent recognition that B cells also play critical role in maintaining peripheral tolerance and suppressing the development or severity of autoimmune diseases. Their immune suppressive function is attributed to relatively rare populations of regulatory B cells (Bregs) that produce anti-inflammatory cytokines including interleukin 10 (IL-10), IL-35 and transforming growth factor-β. The IL-35-producing B cell (i35-Breg) is the newest Breg subset described. i35-Bregs suppress central nervous system autoimmune diseases by inducing infectious tolerance whereby conventional B cells acquire regulatory functions that suppress pathogenic Th17 responses. In this review, we discuss immunobiology of i35-Breg cell, i35-Breg therapies for autoimmune diseases and potential therapeutic strategies for depleting i35-Bregs that suppress immune responses against pathogens and tumor cells.
Identifiants
pubmed: 32755620
pii: S0022-2836(20)30474-5
doi: 10.1016/j.jmb.2020.07.019
pmc: PMC7779660
mid: NIHMS1617137
pii:
doi:
Substances chimiques
Cytokines
0
Interleukins
0
interleukin-35, human
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
166607Subventions
Organisme : Intramural NIH HHS
ID : ZIA EY000350
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Références
Viral Immunol. 2015 Mar;28(2):93-100
pubmed: 25494369
Annu Rev Immunol. 2012;30:221-41
pubmed: 22224776
J Clin Invest. 2017 Mar 1;127(3):772-779
pubmed: 28248202
Immune Netw. 2016 Oct;16(5):305-310
pubmed: 27799876
Eur J Immunol. 1980 Jan;10(1):21-6
pubmed: 6965912
Nat Commun. 2015 Nov 27;6:8991
pubmed: 26612263
Nat Rev Immunol. 2014 Sep;14(9):585-600
pubmed: 25145755
Int Immunol. 2015 Oct;27(10):479-86
pubmed: 26071023
Biochim Biophys Acta. 2011 May;1813(5):878-88
pubmed: 21296109
J Exp Med. 1983 Feb 1;157(2):547-58
pubmed: 6185613
Immunity. 2016 Mar 15;44(3):683-697
pubmed: 26968426
Int Immunol. 2015 Oct;27(10):521-30
pubmed: 25999597
Science. 1969 Nov 7;166(3906):753-5
pubmed: 5823314
J Exp Med. 1998 Jul 20;188(2):287-96
pubmed: 9670041
J Immunol. 2009 Mar 15;182(6):3492-3502
pubmed: 19265127
J Exp Med. 1978 Oct 1;148(4):871-7
pubmed: 308990
J Exp Med. 1996 Dec 1;184(6):2271-8
pubmed: 8976182
Cell Res. 2014 Feb;24(2):161-76
pubmed: 24296781
Cell Immunol. 1982 Mar 15;68(1):104-13
pubmed: 6211248
J Immunol. 2012 Feb 1;188(3):1036-48
pubmed: 22198952
Nat Immunol. 2010 Dec;11(12):1093-101
pubmed: 20953201
J Immunol. 2011 May 15;186(10):5569-79
pubmed: 21464089
J Exp Med. 1997 Nov 17;186(10):1749-56
pubmed: 9362534
Front Immunol. 2020 May 29;11:1051
pubmed: 32547555
Immunity. 2010 Jan 29;32(1):129-40
pubmed: 20079667
Nature. 2015 May 7;521(7550):94-8
pubmed: 25924065
Immunol Rev. 2001 Aug;182:207-14
pubmed: 11722636
J Neuroimmunol. 2011 Oct 28;239(1-2):80-6
pubmed: 21940055
Oncogene. 2007 Mar 22;26(13):1941-8
pubmed: 17001312
J Exp Med. 2001 Jun 4;193(11):F41-6
pubmed: 11390442
Nat Commun. 2017 Sep 28;8(1):719
pubmed: 28959012
Annu Rev Immunol. 2000;18:423-49
pubmed: 10837065
Sci Rep. 2017 Jun 28;7(1):4323
pubmed: 28659587
Immunity. 2015 Apr 21;42(4):607-12
pubmed: 25902480
J Immunol. 2014 Dec 15;193(12):5904-13
pubmed: 25392527
Nat Med. 2014 Jun;20(6):633-41
pubmed: 24743305
Front Immunol. 2017 Oct 05;8:1258
pubmed: 29051763
Cytokine Growth Factor Rev. 2015 Oct;26(5):587-93
pubmed: 26279360
Stem Cell Reports. 2017 May 9;8(5):1214-1225
pubmed: 28494937
J Immunol. 2015 Feb 15;194(4):1395-401
pubmed: 25663677
Immunity. 2014 Dec 18;41(6):1040-51
pubmed: 25484301
J Clin Invest. 2011 Sep;121(9):3645-56
pubmed: 21821911
Eur J Immunol. 2016 Jun;46(6):1343-50
pubmed: 27019190
Nat Immunol. 2017 Mar 22;18(4):374-384
pubmed: 28323260
Medicine (Baltimore). 2018 May;97(19):e0710
pubmed: 29742730
Immunology. 1971 Dec;21(6):903-14
pubmed: 4943147
J Autoimmun. 1990 Jun;3(3):247-55
pubmed: 2397018
J Immunol. 2009 Jun 15;182(12):7459-72
pubmed: 19494269
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):495-504
pubmed: 21176991
Cancer Res. 2011 May 15;71(10):3505-15
pubmed: 21444674
J Biol Chem. 2017 Apr 21;292(16):6644-6656
pubmed: 28280243
Nat Immunol. 2012 Feb 05;13(3):290-9
pubmed: 22306691
Ann Transl Med. 2017 Jan;5(1):23
pubmed: 28164108
J Biol Chem. 2013 Sep 27;288(39):28058-67
pubmed: 23926109
J Immunol. 1968 Sep;101(3):439-45
pubmed: 5692096
Nature. 2014 Mar 20;507(7492):366-370
pubmed: 24572363
Nat Immunol. 2012 Jul 19;13(8):722-8
pubmed: 22814351
Nat Med. 2014 Nov;20(11):1334-9
pubmed: 25326801
Stem Cell Res Ther. 2019 Aug 30;10(1):278
pubmed: 31470892
Curr Pharm Des. 2009;15(18):2095-103
pubmed: 19519447
J Leukoc Biol. 2018 Dec;104(6):1147-1157
pubmed: 30117603
Virol J. 2019 Apr 16;16(1):48
pubmed: 30992023
Immunity. 2014 Dec 18;41(6):878-80
pubmed: 25526301
Autoimmun Rev. 2018 Jul;17(7):665-673
pubmed: 29729445
Immunity. 2018 Jul 17;49(1):120-133.e9
pubmed: 30005826
J Control Release. 2015 Dec 10;219:396-405
pubmed: 26241750
J Virol. 2009 May;83(10):5117-26
pubmed: 19264784
Front Immunol. 2013 Oct 18;4:315
pubmed: 24151492
J Immunol. 2007 Mar 15;178(6):3447-56
pubmed: 17339439
Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12041-6
pubmed: 9342359
Int Ophthalmol. 1990 Oct;14(5-6):303-8
pubmed: 2249907
J Immunol. 2010 Feb 1;184(3):1543-51
pubmed: 20042582
J Immunol. 2012 Apr 1;188(7):3188-98
pubmed: 22368274
Int Immunopharmacol. 2019 May;70:252-259
pubmed: 30851705
Nat Commun. 2015 Jan 22;6:5997
pubmed: 25609381
Sci Transl Med. 2013 Feb 20;5(173):173ra23
pubmed: 23427243
J Immunol. 1995 Aug 1;155(3):1151-64
pubmed: 7636184
Science. 2003 Jun 27;300(5628):2101-4
pubmed: 12829785
Nat Immunol. 2002 Oct;3(10):944-50
pubmed: 12244307
J Exp Med. 1996 Mar 1;183(3):1161-72
pubmed: 8642258
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94
pubmed: 21145125
J Immunol. 2004 Feb 15;172(4):2137-46
pubmed: 14764679
Nat Immunol. 2019 Jun;20(6):724-735
pubmed: 30936494
J Inflamm (Lond). 2017 Aug 7;14:16
pubmed: 28794689
Nature. 2007 Nov 22;450(7169):566-9
pubmed: 18033300
Blood Cells Mol Dis. 2005 Sep-Oct;35(2):94-110
pubmed: 15975838
Immunology. 1970 May;18(5):723-37
pubmed: 4911896
Immunol Rev. 2001 Aug;182:68-79
pubmed: 11722624
Clin Rev Allergy Immunol. 2015 Dec;49(3):327-32
pubmed: 25619872
J Exp Med. 2001 Jun 4;193(11):1285-94
pubmed: 11390435