Overcoming the blood-brain barrier in neurodegenerative disorders and brain tumours.

Animals Blood-Brain Barrier / metabolism Brain Neoplasms / drug therapy Cells, Cultured Drug Delivery Systems Humans Neurodegenerative Diseases / drug therapy Tight Junctions / metabolism

Journal

IET nanobiotechnology
ISSN: 1751-875X
Titre abrégé: IET Nanobiotechnol
Pays: United States
ID NLM: 101303205

Informations de publication

Date de publication:
Aug 2020
Historique:
entrez: 7 8 2020
pubmed: 7 8 2020
medline: 16 2 2021
Statut: ppublish

Résumé

Drug delivery is one of the major challenges in the treatment of central nervous system disorders. The brain needs to be protected from harmful agents, which are done by the capillary network, the so-called blood-brain barrier (BBB). This protective guard also prevents the delivery of therapeutic agents to the brain and limits the effectiveness of treatment. For this reason, various strategies have been explored by scientists for overcoming the BBB from disruption of the BBB to targeted delivery of nanoparticles (NPs) and cells and immunotherapy. In this review, different promising brain drug delivery strategies including disruption of tight junctions in the BBB, enhanced transcellular transport by peptide-based delivery, local delivery strategies, NP delivery, and cell-based delivery have been fully discussed.

Identifiants

DOI: 10.1049/iet-nbt.2019.0351 PMID: 32755952 PMC: PMC8676526
pubmed: 32755952
doi: 10.1049/iet-nbt.2019.0351
pmc: PMC8676526
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

441-448

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Auteurs

Zahra Ebrahimi (Z)

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sam Talaei (S)

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Shahin Aghamiri (S)

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. shahin.aghamiri@sbmu.ac.ir.

Nasser Hashemi Goradel (NH)

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Ali Jafarpour (A)

Students' Scientific Research Center, Virology Division, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Babak Negahdari (B)

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Cellules › Cellules cultivées › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Overcoming the blood-brain barrier in...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions serrées › Overcoming the blood-brain barrier in...