Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo.
Grem1
Gremlin1
bone marrow stromal cells
multiple myeloma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Aug 2020
03 Aug 2020
Historique:
received:
25
06
2020
revised:
24
07
2020
accepted:
29
07
2020
entrez:
7
8
2020
pubmed:
7
8
2020
medline:
7
8
2020
Statut:
epublish
Résumé
In most instances, multiple myeloma (MM) plasma cells (PCs) are reliant on factors made by cells of the bone marrow (BM) stroma for their survival and growth. To date, the nature and cellular composition of the BM tumor microenvironment and the critical factors which drive tumor progression remain imprecisely defined. Our studies show that Gremlin1 (Grem1), a highly conserved protein, which is abundantly secreted by a subset of BM mesenchymal stromal cells, plays a critical role in MM disease development. Analysis of human and mouse BM stromal samples by quantitative PCR showed that
Identifiants
pubmed: 32756430
pii: cancers12082149
doi: 10.3390/cancers12082149
pmc: PMC7464474
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Leukemia and Lymphoma Society
ID : 654718
Organisme : National Health and Medical Research Council
ID : APP1104031
Références
Neoplasia. 2014 Jul;16(7):572-85
pubmed: 25117979
N Engl J Med. 2004 Oct 28;351(18):1860-73
pubmed: 15509819
Expert Rev Anticancer Ther. 2018 Aug;18(8):735-750
pubmed: 29768064
Mol Carcinog. 2016 Dec;55(12):1927-1939
pubmed: 27023728
Nat Commun. 2018 Aug 22;9(1):3363
pubmed: 30135448
Blood. 1993 Dec 15;82(12):3712-20
pubmed: 8260708
Clin Exp Metastasis. 2008;25(4):325-34
pubmed: 17952614
J Histochem Cytochem. 2004 Sep;52(9):1159-67
pubmed: 15314083
Oncol Rep. 2016 Jan;35(1):391-7
pubmed: 26530461
BMC Cancer. 2006 Mar 18;6:74
pubmed: 16545136
J Cell Sci. 2003 May 1;116(Pt 9):1827-35
pubmed: 12665563
Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14842-7
pubmed: 17003113
Cell. 2015 Jan 15;160(1-2):269-84
pubmed: 25594183
Oncogenesis. 2013 Aug 26;2:e66
pubmed: 23978876
Int J Clin Exp Pathol. 2013 Jun 15;6(7):1400-8
pubmed: 23826422
Blood. 2010 Nov 4;116(18):3677-80
pubmed: 20660291
Leukemia. 2019 Feb;33(2):457-468
pubmed: 30046162
Breast Cancer Res. 2019 Sep 18;21(1):109
pubmed: 31533776
Nat Med. 2015 Jan;21(1):62-70
pubmed: 25419707
Eur J Cancer. 2006 Jul;42(11):1564-73
pubmed: 16765041
Lancet Oncol. 2014 Nov;15(12):e538-48
pubmed: 25439696
Ann Lab Med. 2015 Nov;35(6):563-9
pubmed: 26354343
Am J Pathol. 2010 Feb;176(2):575-84
pubmed: 20042676
Neoplasia. 2019 Aug;21(8):777-787
pubmed: 31247457
Mol Carcinog. 2016 Sep;55(9):1343-54
pubmed: 26293751
Leukemia. 2016 May;30(5):1005-17
pubmed: 26710887
Mol Cell. 1998 Apr;1(5):673-83
pubmed: 9660951
Cancer Cell. 2008 Feb;13(2):167-80
pubmed: 18242516
Am Soc Clin Oncol Educ Book. 2016;35:e418-23
pubmed: 27249749
Leukemia. 2012 May;26(5):1073-80
pubmed: 21941367
Nat Commun. 2015 Dec 03;6:8983
pubmed: 26632274
PLoS One. 2017 Mar 27;12(3):e0174565
pubmed: 28346486
Blood Cancer J. 2012 Sep 14;2:e91
pubmed: 22983434
Mol Ther. 2009 Jan;17(1):183-90
pubmed: 18985030
Haematologica. 2014 Jan;99(1):163-71
pubmed: 23935020
J Biol Chem. 2014 Apr 4;289(14):9952-60
pubmed: 24550394
Biol Chem. 2015 Feb;396(2):163-83
pubmed: 25153376
Front Endocrinol (Lausanne). 2019 Jan 08;9:788
pubmed: 30671025
Blood Rev. 2020 Jan;39:100616
pubmed: 31500848
J Pathol. 2020 Jun;251(2):117-122
pubmed: 32297672
Cell. 2007 Oct 19;131(2):324-36
pubmed: 17956733
Am J Pathol. 2013 Nov;183(5):1461-73
pubmed: 24160323
J Gastroenterol. 2013 Jan;48(1):101-8
pubmed: 22706573
Leukemia. 2017 May;31(5):1039-1047
pubmed: 28210004
PLoS One. 2012;7(4):e35100
pubmed: 22514712
Blood. 1995 Feb 15;85(4):929-40
pubmed: 7849315
Leukemia. 2014 Feb;28(2):384-390
pubmed: 23817176
Int J Oncol. 2018 Dec;53(6):2445-2457
pubmed: 30272371
Nat Rev Cancer. 2012 Apr 12;12(5):335-48
pubmed: 22495321
Cancer Res. 2017 Oct 15;77(20):5452-5463
pubmed: 28855206
Leukemia. 2017 Nov;31(11):2443-2448
pubmed: 28620163