μ-conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNa

Animals Conotoxins / toxicity Conus Snail HEK293 Cells Humans NAV1.7 Voltage-Gated Sodium Channel / metabolism Sodium Channel Blockers / toxicity Tetrodotoxin
Conopeptide Conotoxin Pain Voltage-gated sodium channel hNa(v)1.8

Journal

Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333

Informations de publication

Date de publication:
30 Oct 2020
Historique:
received: 23 04 2020
revised: 19 07 2020
accepted: 22 07 2020
pubmed: 8 8 2020
medline: 3 10 2020
entrez: 8 8 2020
Statut: ppublish

Résumé

TsIIIA, the first μ-conotoxin from Conus tessulatus, can selectively inhibit rat tetrodotoxin-resistant sodium channels. TsIIIA also shows potent analgesic activity in a mice hotplate analgesic assay, but its effect on human sodium channels remains unknown. In this study, eight human sodium channel subtypes, hNa

Identifiants

DOI: 10.1016/j.toxicon.2020.07.024 PMID: 32758497
pubmed: 32758497
pii: S0041-0101(20)30328-7
doi: 10.1016/j.toxicon.2020.07.024
pii:
doi:

Substances chimiques

Conotoxins 0
NAV1.7 Voltage-Gated Sodium Channel 0
Sodium Channel Blockers 0
TSIIIA conotoxin, Conus tessulatus 0
Tetrodotoxin 4368-28-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-34

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Manyi Yang (M)

Department of Hepatobiliary and Pancreatic Surgery, NHC Key Laboratory of Nanobiological Technology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Maojun Zhou (M)

Department of Oncology, State Local Joint Engineering Laboratory for Anticancer Drugs, NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address: zhoumaojun@csu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Gastropoda › Conus › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.7 › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › μ-conotoxin TsIIIA, a peptide inhibitor of...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines de la flore et de la faune marines › Tétrodotoxine › μ-conotoxin TsIIIA, a peptide inhibitor of...