Estrogen shields women from COVID-19 complications by reducing ER stress.
Adult
Betacoronavirus
COVID-19
Coronavirus Infections
/ epidemiology
Datasets as Topic
/ statistics & numerical data
Diglycerides
/ metabolism
Disease Resistance
Endoplasmic Reticulum Stress
/ physiology
Estrogens
/ physiology
Female
Humans
Inositol 1,4,5-Trisphosphate
/ metabolism
Male
Middle Aged
Models, Biological
Pakistan
/ epidemiology
Pandemics
Phosphatidylinositol 4,5-Diphosphate
/ metabolism
Pneumonia, Viral
/ epidemiology
SARS-CoV-2
Sex Characteristics
Sex Distribution
Signal Transduction
Type C Phospholipases
/ metabolism
Unfolded Protein Response
Viral Proteins
/ biosynthesis
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
02
06
2020
revised:
21
06
2020
accepted:
27
07
2020
pubmed:
8
8
2020
medline:
21
10
2020
entrez:
8
8
2020
Statut:
ppublish
Résumé
Estrogen hormone acts as a potential key player in providing immunity against certain viral infection. It is found to be associated in providing immunity against acute lungs inflammation and influenza virus by modulating cytokines storm and mediating adaptive immune alterations respectively. Women are less affected by SARS-CoV-2 infection because of the possible influence of estrogen hormone as compared to men. We hypothesized that SARS-CoV-2 causes stress in endoplasmic reticulum (ER) which in turn aggravates the infection, estrogen hormone might play key role in decreasing ER stress by activating estrogen mediated signaling pathways, results in unfolded protein response (UPR). Estrogen governs degradation of phosphotidylinositol 4,5-bisphosphate (PIP
Identifiants
pubmed: 32759016
pii: S0306-9877(20)31612-1
doi: 10.1016/j.mehy.2020.110148
pmc: PMC7390780
pii:
doi:
Substances chimiques
Diglycerides
0
Estrogens
0
Phosphatidylinositol 4,5-Diphosphate
0
Viral Proteins
0
Inositol 1,4,5-Trisphosphate
85166-31-0
Type C Phospholipases
EC 3.1.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110148Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.