Shock waves promote spinal cord repair via TLR3.
Inflammation
Medical devices
Neurological disorders
Neuroscience
Surgery
Journal
JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073
Informations de publication
Date de publication:
06 08 2020
06 08 2020
Historique:
received:
25
10
2019
accepted:
24
06
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
1
6
2021
Statut:
epublish
Résumé
Spinal cord injury (SCI) remains a devastating condition with poor prognosis and very limited treatment options. Affected patients are severely restricted in their daily activities. Shock wave therapy (SWT) has shown potent regenerative properties in bone fractures, wounds, and ischemic myocardium via activation of the innate immune receptor TLR3. Here, we report on the efficacy of SWT for regeneration of SCI. SWT improved motor function and decreased lesion size in WT but not Tlr3-/- mice via inhibition of neuronal degeneration and IL6-dependent recruitment and differentiation of neuronal progenitor cells. Both SWT and TLR3 stimulation enhanced neuronal sprouting and improved neuronal survival, even in human spinal cord cultures. We identified tlr3 as crucial enhancer of spinal cord regeneration in zebrafish. Our findings indicate that TLR3 signaling is involved in neuroprotection and spinal cord repair and suggest that TLR3 stimulation via SWT could become a potent regenerative treatment option.
Identifiants
pubmed: 32759498
pii: 134552
doi: 10.1172/jci.insight.134552
pmc: PMC7455067
doi:
pii:
Substances chimiques
Neuroprotective Agents
0
Toll-Like Receptor 3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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