Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
03
2020
accepted:
21
07
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
7
10
2020
Statut:
epublish
Résumé
Several cohort studies have shown that periodontal disease is associated with an increased risk for stroke. However, it remains unclear whether serum antibody titers for a specific periodontal pathogen are associated with outcome after ischemic stroke, and which kinds of pathogens are associated with ischemic stroke. We examined the relationship between serum IgG titers to periodontal pathogens and outcome in ischemic stroke patients. A total of 445 patients with acute ischemic stroke (194 female [44.0%], mean age 71.9±12.3 years) were registered in this study. Serum IgG titers to 9 periodontal pathogens (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Prevotella nigrescens, Fusobacterium nucleatum, Treponema denticola, Tannerella forsythensis, Campylobacter rectus, Eikenella corrodens) were evaluated using the enzyme-linked immunosorbent assay (ELISA) method. An unfavorable outcome was defined as a 3 or higher on the modified Rankin Scale. The proportion of patients with unfavorable outcome was 25.4% (113 patients). Based on multivariate logistic regression analysis, numbers of IgG antibodies positive for periodontal pathogens (odds ratio 1.20, 95% CI 1.02-1.41, p = 0.03) were independent predictors of unfavorable outcome in ischemic stroke patients.
Identifiants
pubmed: 32760103
doi: 10.1371/journal.pone.0237185
pii: PONE-D-20-09034
pmc: PMC7410289
doi:
Substances chimiques
Antibodies, Bacterial
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0237185Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Clin Microbiol. 2002 Feb;40(2):512-8
pubmed: 11825965
Infect Immun. 2000 Jun;68(6):3140-6
pubmed: 10816455
Am J Med. 2012 Jun;125(6):568-75
pubmed: 22483056
J Clin Periodontol. 2008 Jun;35(6):473-8
pubmed: 18410396
J Neurosci. 2007 Apr 18;27(16):4403-12
pubmed: 17442825
Cerebrovasc Dis. 2012;34(5-6):385-92
pubmed: 23207319
Lancet. 2005 Nov 19;366(9499):1809-20
pubmed: 16298220
J Periodontal Res. 2012 Aug;47(4):470-8
pubmed: 22220967
J Intern Med. 1989 Mar;225(3):179-84
pubmed: 2703800
J Med Microbiol. 2008 May;57(Pt 5):668-671
pubmed: 18436604
Oral Microbiol Immunol. 2002 Apr;17(2):113-8
pubmed: 11929559
J Oral Microbiol. 2017 Jan 17;9(1):1270602
pubmed: 28326151
Clin Exp Immunol. 2007 Sep;149(3):445-52
pubmed: 17645769
J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):1214-8
pubmed: 23761916
Eur J Neurol. 2014 Sep;21(9):1155-61, e66-7
pubmed: 24712659
Circulation. 2005 Feb 8;111(5):576-82
pubmed: 15699278
Clin Exp Immunol. 2020 Jun;200(3):302-309
pubmed: 32155293
Can J Neurol Sci. 2003 Aug;30(3):266-8
pubmed: 12945954
J Periodontol. 2009 Apr;80(4):634-47
pubmed: 19335084
J Periodontal Res. 2006 Jun;41(3):228-34
pubmed: 16677293
Ann Periodontol. 1998 Jul;3(1):161-74
pubmed: 9722700
Stroke. 2013 Apr;44(4):1026-30
pubmed: 23422085
J Clin Periodontol. 2014 Jan;41(1):1-10
pubmed: 24102517
Arch Intern Med. 2000 Oct 9;160(18):2749-55
pubmed: 11025784
J Neuroinflammation. 2011 Nov 24;8:164
pubmed: 22114895
Stroke. 2004 Sep;35(9):2020-3
pubmed: 15232116
J Neurosci. 2008 Sep 17;28(38):9451-62
pubmed: 18799677
Int J Stroke. 2020 Feb;15(2):175-187
pubmed: 30794103
Ann Periodontol. 2003 Dec;8(1):38-53
pubmed: 14971247
Infect Immun. 1996 Jun;64(6):2094-100
pubmed: 8675312
J Dent Res. 2012 Dec;91(12):1190-5
pubmed: 23018816
Infect Immun. 2014 May;82(5):1914-20
pubmed: 24566622
Stroke. 2018 Feb;49(2):355-362
pubmed: 29335336
Circulation. 2005 Jul 5;112(1):19-24
pubmed: 15983248
Alzheimers Dement. 2012 May;8(3):196-203
pubmed: 22546352
J Gastroenterol. 2018 Feb;53(2):269-280
pubmed: 28741270
Curr Opin Microbiol. 2015 Feb;23:141-7
pubmed: 25576662
Stroke. 1993 Jan;24(1):35-41
pubmed: 7678184
Am J Kidney Dis. 2009 Jun;53(6):982-92
pubmed: 19339088
Oral Microbiol Immunol. 2006 Oct;21(5):314-8
pubmed: 16922931
J Periodontal Res. 2008 Feb;43(1):103-10
pubmed: 18230111