Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development.
Adult
Aged
Antibodies, Bacterial
/ blood
C-Reactive Protein
/ metabolism
Disease Progression
Female
Humans
Immunity, Humoral
Lipids
/ blood
Male
Middle Aged
Mycobacterium tuberculosis
/ immunology
Nutritional Status
/ immunology
Serum Albumin, Human
/ metabolism
Tuberculosis Vaccines
/ immunology
Tuberculosis, Pulmonary
/ blood
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
09
2019
accepted:
20
07
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Nutritional status contributes to the regulation of immune responses against pathogens, and malnutrition has been considered as a risk factor for tuberculosis (TB). Mycobacterium tuberculosis (Mtb), the causative agent of TB, can modulate host lipid metabolism and induce lipid accumulation in macrophages, where the bacilli adopt a dormant phenotype. In addition, serum lipid components play dual roles in the regulation of and protection from Mtb infection. We analyzed the relationship between nutritional status and the humoral immune response in TB patients. We found that serum HDL levels are positively correlated with the serum IgA specific for Mtb antigens. Analysis of the relationship between serum nutritional parameters and clinical parameters in TB patients showed that serum albumin and CRP levels were negatively correlated before treatment. We also observed reduced serum LDL levels in TB patients following treatment. These findings may provide insight into the role of serum lipids in host immune responses against Mtb infection. Furthermore, improving the nutritional status may enhance vaccination efficacy.
Identifiants
pubmed: 32760105
doi: 10.1371/journal.pone.0237062
pii: PONE-D-19-26473
pmc: PMC7410285
doi:
Substances chimiques
Antibodies, Bacterial
0
Lipids
0
Tuberculosis Vaccines
0
C-Reactive Protein
9007-41-4
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0237062Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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