Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis.
parvovirus B19
spherocytosis
tubulointerstitial nephritis
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
10
06
2020
accepted:
02
07
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
8
8
2020
Statut:
epublish
Résumé
Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
Sections du résumé
BACKGROUND
BACKGROUND
Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis.
METHODS
METHODS
Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure.
RESULTS
RESULTS
A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells.
CONCLUSIONS
CONCLUSIONS
Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
Identifiants
pubmed: 32760751
doi: 10.1093/ofid/ofaa288
pii: ofaa288
pmc: PMC7395673
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofaa288Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
Cell. 2018 Oct 4;175(2):530-543.e24
pubmed: 30220458
Lancet. 1975 Jan 11;1(7898):72-3
pubmed: 46024
Pediatr Nephrol. 2003 Sep;18(9):966-7
pubmed: 12883967
J Microbiol Immunol Infect. 2019 Aug;52(4):534-541
pubmed: 31257106
Clin Nephrol. 2005 Oct;64(4):249-57
pubmed: 16240895
J Virol. 2010 Nov;84(22):11737-46
pubmed: 20826697
Am J Transplant. 2008 Jun;8(6):1340-4
pubmed: 18522549
Arch Virol. 2014 May;159(5):1239-47
pubmed: 24212889
Nat Commun. 2017 Apr 04;8:14930
pubmed: 28374737
Bioconjug Chem. 2015 Sep 16;26(9):1923-30
pubmed: 26240997
BMC Nephrol. 2016 Sep 06;17(1):125
pubmed: 27600725
Transfus Clin Biol. 2016 Feb;23(1):5-12
pubmed: 26778837
Blood. 2005 Nov 15;106(10):3449-56
pubmed: 16076874