Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept.
Blood pressure
Gut
Hypertension
Salt
Sodium-proton-exchanger
Journal
International journal of cardiology. Heart & vasculature
ISSN: 2352-9067
Titre abrégé: Int J Cardiol Heart Vasc
Pays: Ireland
ID NLM: 101649525
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
18
05
2020
revised:
24
06
2020
accepted:
07
07
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
8
8
2020
Statut:
epublish
Résumé
Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure. In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage.
Identifiants
pubmed: 32760780
doi: 10.1016/j.ijcha.2020.100591
pii: S2352-9067(20)30289-X
pii: 100591
pmc: PMC7390783
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100591Informations de copyright
© 2020 Published by Elsevier B.V.
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