Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study.
Fibrosis
Hepatosplenic schistosomiasis
Liver stiffness
Metabolism
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
22
03
2019
revised:
20
08
2019
accepted:
20
07
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
8
8
2020
Statut:
epublish
Résumé
Cirrhosis commonly complicates portal hypertension worldwide but in Zambia hepatosplenic schistosomiasis (HSS) dominates as the cause of portal hypertension. We need easier and non-invasive ways to assess HSS. Transient elastography (TE), a measure of liver stiffness can diagnose liver cirrhosis. TE remains unexplored in HSS patients, who generally have normal liver parenchyma. We aimed to explore liver stiffness in HSS. This nested case control study was conducted at the University Teaching Hospital, Lusaka, Zambia between January 2015 and January 2016. We enrolled 48 adults with HSS and 22 healthy controls. We assessed liver stiffness using TE while plasma hyaluronan was used to assess liver fibrosis. Plasma tumor necrosis factor receptor 1 (TNFR1) and soluble cluster of differentiation 14 (sCD14) were used to assess inflammation. The median (interquartile range) liver stiffness was higher in patients, 9.5 kPa (7.8, 12.8) than in controls, 4.7 kPa (4.0, 5.4),
Identifiants
pubmed: 32760834
doi: 10.1016/j.heliyon.2020.e04534
pii: S2405-8440(20)31378-5
pii: e04534
pmc: PMC7393539
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e04534Subventions
Organisme : Medical Research Council
ID : MR/K007394/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U01 AI069924
Pays : United States
Informations de copyright
© 2020 Published by Elsevier Ltd.
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