Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation.
ANP, atrial natriuretic peptide
ARNI
ARNI, angiotensin-receptor neprilysin-inhibitor
BNP, B-type natriuretic peptide
CMRI+LE, cardiac magnetic resonance and late enhancement
HF, heart failure
HFrEF, heart failure with reduced ejection fraction
LV, left ventricular
NEP, neprilysin
NT-proBNP, N-terminal pro-B-type natriuretic peptide
Q1 to Q3, 25th to 75th percentile
RA, right atrial
RV, right ventricular
biomarker
gene expression
left atrial, left atrial
mRNA, messenger RNA
metalloproteinase
neprilysin
qPCR, real-time polymerase chain reaction
translational model of heart failure
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
30
09
2019
revised:
08
05
2020
accepted:
08
05
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
8
8
2020
Statut:
epublish
Résumé
Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher NEP content and/or activity compared with any other organ; 2) NEP seems to be downregulated under HF conditions; and 3) that the value of plasma NEP concentrations and activity as biomarkers is questionable. For the first time, these data provide basic knowledge on HF-related pathophysiological alterations of the NEP system and contribute to understanding the mechanism of action of angiotensin-receptor neprilysin-inhibitors, which remains elusive despite broad clinical applications.
Identifiants
pubmed: 32760858
doi: 10.1016/j.jacbts.2020.05.011
pii: S2452-302X(20)30253-9
pmc: PMC7393434
doi:
Types de publication
Journal Article
Langues
eng
Pagination
715-726Informations de copyright
© 2020 The Authors.
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