Cell-Permeable Calpain Inhibitor SJA6017 Provides Functional Protection to Spinal Motoneurons Exposed to MPP

Animals Apoptosis / drug effects Calpain / metabolism Dipeptides / pharmacology Glycoproteins / pharmacology Motor Neurons / drug effects Neuroprotective Agents / pharmacology Reactive Oxygen Species / metabolism Spinal Cord / cytology Substantia Nigra / drug effects
Apoptosis Calpain Motor proteins Oxidative stress Parkinson’s

Journal

Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 23 06 2020
accepted: 27 07 2020
revised: 17 07 2020
pubmed: 8 8 2020
medline: 10 7 2021
entrez: 8 8 2020
Statut: ppublish

Résumé

Extra-nigral central nervous system sites have been found to be affected in Parkinson's disease (PD). In addition to substantia nigra, degeneration of spinal cord motor neurons may play a role in the motor symptoms of PD. To this end, hybrid rodent VSC 4.1 cells differentiated into motoneurons were used as a cell culture model following exposure to Parkinsonian neurotoxicant MPP

Identifiants

DOI: 10.1007/s12640-020-00264-3 PMID: 32761446 PMC: PMC9453439
pubmed: 32761446
doi: 10.1007/s12640-020-00264-3
pii: 10.1007/s12640-020-00264-3
pmc: PMC9453439
mid: NIHMS1618765
doi:

Substances chimiques

Dipeptides 0
Glycoproteins 0
N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal 0
Neuroprotective Agents 0
Reactive Oxygen Species 0
calpain inhibitors 0
Calpain EC 3.4.22.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

640-649

Subventions

Organisme : NINDS NIH HHS
ID : R01NS062327-01A2
Pays : United States
Organisme : South Carolina State Spinal Cord Research Fund
ID : SCIRF-2015P-01, SCIRF-2015P-04, SCIRF-2015-I-01, SCIRF-2016 I-03, and SCIRF #2018 I-01
Organisme : U.S. Department of Veterans Affairs
ID : 1I01BX004269-01
Organisme : BLRD VA
ID : I01 BX004269
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS062327
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS062327-01A2
Pays : United States

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Auteurs

Supriti Samantaray (S)

Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas St., MSC606 Suite 301, Charleston, SC, 29425, USA.

Varduhi H Knaryan (VH)

Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas St., MSC606 Suite 301, Charleston, SC, 29425, USA.

Angelo M Del Re (A)

Division of Neuroscience Research and Center for Drug & Alcohol Programs, Medical University of South Carolina, Charleston, SC, USA.

John J Woodward (JJ)

Division of Neuroscience Research and Center for Drug & Alcohol Programs, Medical University of South Carolina, Charleston, SC, USA.

Donald C Shields (DC)

Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas St., MSC606 Suite 301, Charleston, SC, 29425, USA.

Mitsuyoshi Azuma (M)

Kobe Creative Center, Senju Pharmaceutical Corporation Limited, Kobe, 651-2241, Japan.
Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR, USA.

Jun Inoue (J)

Kobe Creative Center, Senju Pharmaceutical Corporation Limited, Kobe, 651-2241, Japan.

Swapan K Ray (SK)

Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.

Naren L Banik (NL)

Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas St., MSC606 Suite 301, Charleston, SC, 29425, USA. baniknl@musc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Calpain › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Dipeptides › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Cell-Permeable Calpain Inhibitor SJA6017...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Cell-Permeable Calpain Inhibitor SJA6017...