Pharmacotherapy of Tinnitus.
Acute tinnitus
Chronic tinnitus
Drug therapy
Local
Objective tinnitus
Pharmacology
Subjective tinnitus
Systemic
Journal
Current topics in behavioral neurosciences
ISSN: 1866-3370
Titre abrégé: Curr Top Behav Neurosci
Pays: Germany
ID NLM: 101535383
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
8
8
2020
medline:
1
9
2021
entrez:
8
8
2020
Statut:
ppublish
Résumé
Tinnitus is a common symptom for which there is in most cases no causal therapy. The search for an improvement of tinnitus through pharmacological interventions has a long tradition. The observation that tinnitus can be transiently suppressed by the use of lidocaine has shown that the symptom is susceptible to pharmacotherapy. So far, however, no medication has been found for either acute or chronic subjective tinnitus that reliably leads to a long-term reduction or even complete disappearance of the symptom for the majority of tinnitus sufferers. Nevertheless, in everyday clinical life, drugs are frequently used, usually off-label, to relieve tinnitus or tinnitus-associated symptoms (e.g. sleep disturbance, depression, anxiety disorder or hearing loss). This chapter shows the different approaches to acute and chronic subjective tinnitus by means of pharmacotherapeutic interventions. Furthermore, this review reports on the scientific studies carried out in this area in recent years and explains the difficulties in finding a suitable medication for most forms of tinnitus. In addition, it reports on the pharmacotherapeutic options for objective tinnitus and describes the development of tinnitus as a side effect of certain drugs. Finally, possible target structures are mentioned, which should possibly be addressed in pharmacological studies in the near future.
Identifiants
pubmed: 32761509
doi: 10.1007/7854_2020_169
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-212Informations de copyright
© 2020. Springer Nature Switzerland AG.
Références
Ahmadzai N, Kilty S, Cheng W, Esmaeilisaraji L, Wolfe D, Bonaparte JP et al (2019) A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. PLoS One 14(9):e0221713. https://doi.org/10.1371/journal.pone.0221713
doi: 10.1371/journal.pone.0221713
pubmed: 31498809
pmcid: 6733451
An YH, Yu KK, Kwak MY, Yoon SW, Shim HJ (2014) Prognostic factors for the outcomes of intratympanic dexamethasone in the treatment of acute subjective tinnitus. Otol Neurotol 35(8):1330–1337. https://doi.org/10.1097/MAO.0000000000000526
doi: 10.1097/MAO.0000000000000526
pubmed: 25080038
Attias J, Weisz G, Almog S, Shahar A, Wiener M, Joachims Z et al (1994) Oral magnesium intake reduces permanent hearing loss induced by noise exposure. Am J Otolaryngol 15(1):26–32. https://doi.org/10.1016/0196-0709(94)90036-1
doi: 10.1016/0196-0709(94)90036-1
pubmed: 8135325
Azevedo AA, Figueiredo RR (2007) Treatment of tinnitus with acamprosate. Prog Brain Res 166:273–277. https://doi.org/10.1016/S0079-6123(07)66025-7
doi: 10.1016/S0079-6123(07)66025-7
pubmed: 17956791
Baguley DM, Prayuenyong P (2020) Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy. Cancer Chemother Pharmacol 85(2):245–250. https://doi.org/10.1007/s00280-019-04012-z
doi: 10.1007/s00280-019-04012-z
pubmed: 31865419
Baguley DM, Jones S, Wilkins I, Axon PR, Moffat DA (2005) The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study. Otol Neurotol 26(2):169–176. https://doi.org/10.1097/00129492-200503000-00007
doi: 10.1097/00129492-200503000-00007
pubmed: 15793400
Baguley D, McFerran D, Hall D (2013) Tinnitus. Lancet 382(9904):1600–1607. https://doi.org/10.1016/S0140-6736(13)60142-7
doi: 10.1016/S0140-6736(13)60142-7
pubmed: 23827090
Bahmad FM Jr, Venosa AR, Oliveira CA (2006) Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin. Int Tinnitus J 12(2):140–144. https://www.ncbi.nlm.nih.gov/pubmed/17260879
pubmed: 17260879
Baldo P, Doree C, Molin P, McFerran D, Cecco S (2012) Antidepressants for patients with tinnitus. Cochrane Database Syst Rev 9:CD003853. https://doi.org/10.1002/14651858.CD003853.pub3
doi: 10.1002/14651858.CD003853.pub3
Bauer CA, Brozoski TJ (2001) Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. J Assoc Res Otolaryngol 2(1):54–64. https://doi.org/10.1007/s101620010030
doi: 10.1007/s101620010030
pubmed: 11545150
pmcid: 3201094
Bayar N, Boke B, Turan E, Belgin E (2001) Efficacy of amitriptyline in the treatment of subjective tinnitus. J Otolaryngol 30(5):300–303. https://doi.org/10.2310/7070.2001.19597
doi: 10.2310/7070.2001.19597
pubmed: 11771024
Becatti M, Marcucci R, Mannucci A, Gori AM, Giusti B, Sofi F et al (2017) Erythrocyte membrane fluidity alterations in sudden sensorineural hearing loss patients: the role of oxidative stress. Thromb Haemost 117(12):2334–2345. https://doi.org/10.1160/TH17-05-0356
doi: 10.1160/TH17-05-0356
pubmed: 29212121
Berger JI, Coomber B, Hill S, Alexander SPH, Owen W, Palmer AR et al (2017) Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs. Hear Res 356:51–62. https://doi.org/10.1016/j.heares.2017.10.012
doi: 10.1016/j.heares.2017.10.012
pubmed: 29108871
pmcid: 5714060
Bharadwaj HM, Mai AR, Simpson JM, Choi I, Heinz MG, Shinn-Cunningham BG (2019) Non-invasive assays of cochlear synaptopathy – candidates and considerations. Neuroscience 407:53–66. https://doi.org/10.1016/j.neuroscience.2019.02.031
doi: 10.1016/j.neuroscience.2019.02.031
pubmed: 30853540
Bhatta P, Dhukhwa A, Sheehan K, Al Aameri RFH, Borse V, Ghosh S et al (2019) Capsaicin protects against cisplatin ototoxicity by changing the STAT3/STAT1 ratio and activating cannabinoid (CB2) receptors in the cochlea. Sci Rep 9(1):4131. https://doi.org/10.1038/s41598-019-40425-9
doi: 10.1038/s41598-019-40425-9
pubmed: 30858408
pmcid: 6411993
Bhimrao SK, Masterson L, Baguley D (2012) Systematic review of management strategies for middle ear myoclonus. Otolaryngol Head Neck Surg 146(5):698–706. https://doi.org/10.1177/0194599811434504
doi: 10.1177/0194599811434504
pubmed: 22261497
Bing D, Lee SC, Campanelli D, Xiong H, Matsumoto M, Panford-Walsh R et al (2015) Cochlear NMDA receptors as a therapeutic target of noise-induced tinnitus. Cell Physiol Biochem 35(5):1905–1923. https://doi.org/10.1159/000374000
doi: 10.1159/000374000
pubmed: 25871611
Bonnet U (2014) Decompensated chronic tinnitus and high-dose benzodiazepine dependence. Between Scylla and Charybdis. Nervenarzt 85(7):865–869. https://doi.org/10.1007/s00115-012-3670-y
doi: 10.1007/s00115-012-3670-y
pubmed: 23238691
Brien JA (1993) Ototoxicity associated with salicylates. A brief review. Drug Saf 9(2):143–148. https://doi.org/10.2165/00002018-199309020-00006
doi: 10.2165/00002018-199309020-00006
pubmed: 8397891
Brozoski TJ, Wisner KW, Odintsov B, Bauer CA (2013) Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model. PLoS One 8(10):e77674. https://doi.org/10.1371/journal.pone.0077674
doi: 10.1371/journal.pone.0077674
pubmed: 24282480
pmcid: 3834860
Cederroth CR, Canlon B, Langguth B (2013) Hearing loss and tinnitus--are funders and industry listening? Nat Biotechnol 31(11):972–974. https://doi.org/10.1038/nbt.2736
doi: 10.1038/nbt.2736
pubmed: 24213768
Cederroth CR, Dyhrfjeld-Johnsen J, Langguth B (2018) An update: emerging drugs for tinnitus. Expert Opin Emerg Drugs 23(4):251–260. https://doi.org/10.1080/14728214.2018.1555240
doi: 10.1080/14728214.2018.1555240
pubmed: 30522352
Cederroth CR, Gallus S, Hall DA, Kleinjung T, Langguth B, Maruotti A et al (2019) Editorial: towards an understanding of tinnitus heterogeneity. Front Aging Neurosci 11:53. https://doi.org/10.3389/fnagi.2019.00053
doi: 10.3389/fnagi.2019.00053
pubmed: 30941029
pmcid: 6433929
Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA et al (2019) Clinical practice guideline: sudden hearing loss (update). Otolaryngol Head Neck Surg 161(1_suppl):S1–S45. https://doi.org/10.1177/0194599819859885
doi: 10.1177/0194599819859885
pubmed: 31369359
Cianfrone G, Pentangelo D, Cianfrone F, Mazzei F, Turchetta R, Orlando MP et al (2011) Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci 15(6):601–636. https://www.ncbi.nlm.nih.gov/pubmed/21796866
pubmed: 21796866
Clemens E, Meijer AJ, Broer L, Langer T, van der Kooi AL, Uitterlinden AG et al (2019a) Genetic determinants of ototoxicity during and after childhood cancer treatment: protocol for the PanCareLIFE study. JMIR Res Protoc 8(3):e11868. https://doi.org/10.2196/11868
doi: 10.2196/11868
pubmed: 30888333
pmcid: 6444213
Clemens E, van den Heuvel-Eibrink MM, Mulder RL, Kremer LCM, Hudson MM, Skinner R et al (2019b) Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium. Lancet Oncol 20(1):e29–e41. https://doi.org/10.1016/S1470-2045(18)30858-1
doi: 10.1016/S1470-2045(18)30858-1
pubmed: 30614474
pmcid: 7549756
Coelho C, Figueiredo R, Frank E, Burger J, Schecklmann M, Landgrebe M et al (2012) Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study. Audiol Neurootol 17(3):179–188. https://doi.org/10.1159/000335657
doi: 10.1159/000335657
pubmed: 22302057
Dang J, Carol Liu YC (2019) Treatment of objective tinnitus with transpalatal Botox((R)) injection in a pediatric patient with middle ear myoclonus: a case report. Int J Pediatr Otorhinolaryngol 116:22–24. https://doi.org/10.1016/j.ijporl.2018.09.024
doi: 10.1016/j.ijporl.2018.09.024
pubmed: 30554701
de Azevedo AA, Langguth B, de Oliveira PM, Rodrigues Figueiredo R (2009) Tinnitus treatment with piribedil guided by electrocochleography and acoustic otoemissions. Otol Neurotol 30(5):676–680. https://doi.org/10.1097/MAO.0b013e3181ab8fd5
doi: 10.1097/MAO.0b013e3181ab8fd5
pubmed: 19574947
De Ridder D, Elgoyhen AB, Romo R, Langguth B (2011) Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci U S A 108(20):8075–8080. https://doi.org/10.1073/pnas.1018466108
doi: 10.1073/pnas.1018466108
pubmed: 21502503
pmcid: 3100980
De Ridder D, Vanneste S, Langguth B, Llinas R (2015) Thalamocortical dysrhythmia: a theoretical update in tinnitus. Front Neurol 6:124. https://doi.org/10.3389/fneur.2015.00124
doi: 10.3389/fneur.2015.00124
pubmed: 26106362
pmcid: 4460809
Dehkordi MA, Abolbashari S, Taheri R, Einolghozati S (2011) Efficacy of gabapentin on subjective idiopathic tinnitus: a randomized, double-blind, placebo-controlled trial. Ear Nose Throat J 90(4):150–158. https://doi.org/10.1177/014556131109000405
doi: 10.1177/014556131109000405
pubmed: 21500166
Denk DM, Heinzl H, Franz P, Ehrenberger K (1997) Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol 117(6):825–830. https://doi.org/10.3109/00016489709114208
doi: 10.3109/00016489709114208
pubmed: 9442821
Ding D, McFadden SL, Woo JM, Salvi RJ (2002) Ethacrynic acid rapidly and selectively abolishes blood flow in vessels supplying the lateral wall of the cochlea. Hear Res 173(1–2):1–9. https://doi.org/10.1016/s0378-5955(02)00585-3
doi: 10.1016/s0378-5955(02)00585-3
pubmed: 12372630
Dobie RA (1999) A review of randomized clinical trials in tinnitus. Laryngoscope 109(8):1202–1211. https://doi.org/10.1097/00005537-199908000-00004
doi: 10.1097/00005537-199908000-00004
pubmed: 10443820
Domeisen H, Hotz MA, Hausler R (1998) Caroverine in tinnitus treatment. Acta Otolaryngol 118(4):606–608. https://doi.org/10.1080/00016489850154801
doi: 10.1080/00016489850154801
pubmed: 9726691
Eggermont JJ (2008) Role of auditory cortex in noise- and drug-induced tinnitus. Am J Audiol 17(2):S162–S169. https://doi.org/10.1044/1059-0889(2008/07-0025)
doi: 10.1044/1059-0889(2008/07-0025)
pubmed: 18978202
Ehrenberger K (2005) Topical administration of Caroverine in somatic tinnitus treatment: proof-of-concept study. Int Tinnitus J 11(1):34–37. https://www.ncbi.nlm.nih.gov/pubmed/16419686
pubmed: 16419686
Elgoyhen AB, Langguth B, Vanneste S, De Ridder D (2012) Tinnitus: network pathophysiology-network pharmacology. Front Syst Neurosci 6:1. https://doi.org/10.3389/fnsys.2012.00001
doi: 10.3389/fnsys.2012.00001
pubmed: 22291622
pmcid: 3265967
Elgoyhen AB, Langguth B, Nowak W, Schecklmann M, De Ridder D, Vanneste S (2014) Identifying tinnitus-related genes based on a side-effect network analysis. CPT Pharmacometrics Syst Pharmacol 3:e97. https://doi.org/10.1038/psp.2013.75
doi: 10.1038/psp.2013.75
pubmed: 24477090
pmcid: 3910011
Feng H, Yin SH, Tang AZ, Tan SH (2011) Salicylate initiates apoptosis in the spiral ganglion neuron of guinea pig cochlea by activating caspase-3. Neurochem Res 36(6):1108–1115. https://doi.org/10.1007/s11064-011-0455-9
doi: 10.1007/s11064-011-0455-9
pubmed: 21451968
Figueiredo RR, Langguth B, Mello de Oliveira P, Aparecida de Azevedo A (2008) Tinnitus treatment with memantine. Otolaryngol Head Neck Surg 138(4):492–496. https://doi.org/10.1016/j.otohns.2007.11.027
doi: 10.1016/j.otohns.2007.11.027
pubmed: 18359360
Fransson AE, Kisiel M, Pirttila K, Pettersson C, Videhult Pierre P, Laurell GFE (2017) Hydrogen inhalation protects against ototoxicity induced by intravenous cisplatin in the guinea pig. Front Cell Neurosci 11:280. https://doi.org/10.3389/fncel.2017.00280
doi: 10.3389/fncel.2017.00280
pubmed: 28955207
pmcid: 5601388
Gul F, Muderris T, Yalciner G, Sevil E, Bercin S, Ergin M et al (2017) A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol 274(3):1301–1308. https://doi.org/10.1007/s00405-016-4301-1
doi: 10.1007/s00405-016-4301-1
pubmed: 27614879
Han SS, Nam EC, Won JY, Lee KU, Chun W, Choi HK et al (2012) Clonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba. J Neurol Neurosurg Psychiatry 83(8):821–827. https://doi.org/10.1136/jnnp-2012-302273
doi: 10.1136/jnnp-2012-302273
pubmed: 22626945
Hesse G, Laubert A (2010) Pharmacotherapy of acute and chronic hearing loss. HNO 58(10):990–998. https://doi.org/10.1007/s00106-010-2179-6
doi: 10.1007/s00106-010-2179-6
pubmed: 20811867
Hoekstra CE, Rynja SP, van Zanten GA, Rovers MM (2011) Anticonvulsants for tinnitus. Cochrane Database Syst Rev 7:CD007960. https://doi.org/10.1002/14651858.CD007960.pub2
doi: 10.1002/14651858.CD007960.pub2
Hulshof JH, Vermeij P (1985) The value of carbamazepine in the treatment of tinnitus. ORL J Otorhinolaryngol Relat Spec 47(5):262–266. https://doi.org/10.1159/000275781
doi: 10.1159/000275781
pubmed: 3900856
Hwang SM, Lim SH, Oh DJ, Kim SK, Jung HH, Im GJ (2016) Effect of tianeptine on depressed tinnitus patients. J Audiol Otol 20(2):90–96. https://doi.org/10.7874/jao.2016.20.2.90
doi: 10.7874/jao.2016.20.2.90
pubmed: 27626082
pmcid: 5020574
Jalali MM, Kousha A, Naghavi SE, Soleimani R, Banan R (2009) The effects of alprazolam on tinnitus: a cross-over randomized clinical trial. Med Sci Monit 15(11):PI55–PI60. https://www.ncbi.nlm.nih.gov/pubmed/19865063
pubmed: 19865063
Johnson RM, Brummett R, Schleuning A (1993) Use of alprazolam for relief of tinnitus. A double-blind study. Arch Otolaryngol Head Neck Surg 119(8):842–845. https://doi.org/10.1001/archotol.1993.01880200042006
doi: 10.1001/archotol.1993.01880200042006
pubmed: 8343245
Juan JS, Basura GJ (2019) Tinnitus management in lateral skull base lesions. J Neurol Surg B Skull Base 80(2):125–131. https://doi.org/10.1055/s-0038-1676308
doi: 10.1055/s-0038-1676308
pubmed: 30931219
Jufas NE, Wood R (2015) The use of benzodiazepines for tinnitus: systematic review. J Laryngol Otol 129(Suppl 3):S14–S22. https://doi.org/10.1017/S0022215115000808
doi: 10.1017/S0022215115000808
pubmed: 25858126
Kaffenberger TM, Mandal R, Schaitkin BM, Hirsch BE (2017) Palatal botulinum toxin as a novel therapy for objective tinnitus in forced eyelid closure syndrome. Laryngoscope 127(5):1199–1201. https://doi.org/10.1002/lary.26191
doi: 10.1002/lary.26191
pubmed: 27717035
Kalappa BI, Soh H, Duignan KM, Furuya T, Edwards S, Tzingounis AV et al (2015) Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus. J Neurosci 35(23):8829–8842. https://doi.org/10.1523/JNEUROSCI.5176-14.2015
doi: 10.1523/JNEUROSCI.5176-14.2015
pubmed: 26063916
pmcid: 4461688
Kara E, Aydin K, Akbulut AA, Karakol SN, Durmaz S, Yener HM et al (2020) Assessment of hidden hearing loss in normal hearing individuals with and without tinnitus. J Int Adv Otol 16:87. https://doi.org/10.5152/iao.2020.7062
doi: 10.5152/iao.2020.7062
pubmed: 32209515
pmcid: 7224424
Kay NJ (1981) Oral chemotherapy in tinnitus. Br J Audiol 15(2):123–124. https://doi.org/10.3109/03005368109081425
doi: 10.3109/03005368109081425
pubmed: 7225648
Kleinjung T, Langguth B (2020) Avenue for future tinnitus treatments. Otolaryngol Clin North Am. https://doi.org/10.1016/j.otc.2020.03.013
Krause E, Heinen F, Gurkov R (2010) Difference in outcome of botulinum toxin treatment of essential palatal tremor in children and adults. Am J Otolaryngol 31(2):91–95. https://doi.org/10.1016/j.amjoto.2008.11.007
doi: 10.1016/j.amjoto.2008.11.007
pubmed: 20015723
Kucharava K, Sekulic-Jablanovic M, Horvath L, Bodmer D, Petkovic V (2019) Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway. Cell Death Dis 10(2):110. https://doi.org/10.1038/s41419-019-1386-7
doi: 10.1038/s41419-019-1386-7
pubmed: 30728348
pmcid: 6365508
Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T (2016) Synthesis and evaluation of potent KCNQ2/3-specific channel activators. Mol Pharmacol 89(6):667–677. https://doi.org/10.1124/mol.115.103200
doi: 10.1124/mol.115.103200
pubmed: 27005699
Landgrebe M, Zeman F, Koller M, Eberl Y, Mohr M, Reiter J et al (2010) The Tinnitus Research Initiative (TRI) database: a new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome. BMC Med Inform Decis Mak 10:42. https://doi.org/10.1186/1472-6947-10-42
doi: 10.1186/1472-6947-10-42
pubmed: 20682024
pmcid: 2920857
Landier W (2016) Ototoxicity and cancer therapy. Cancer 122(11):1647–1658. https://doi.org/10.1002/cncr.29779
doi: 10.1002/cncr.29779
pubmed: 26859792
Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O (2013) Understanding platinum-induced ototoxicity. Trends Pharmacol Sci 34(8):458–469. https://doi.org/10.1016/j.tips.2013.05.006
doi: 10.1016/j.tips.2013.05.006
pubmed: 23769626
Langguth B, Landgrebe M, Kleinjung T, Sand GP, Hajak G (2011) Tinnitus and depression. World J Biol Psychiatry 12(7):489–500. https://doi.org/10.3109/15622975.2011.575178
doi: 10.3109/15622975.2011.575178
pubmed: 21568629
Langguth B, Kreuzer PM, Kleinjung T, De Ridder D (2013) Tinnitus: causes and clinical management. Lancet Neurol 12(9):920–930. https://doi.org/10.1016/S1474-4422(13)70160-1
doi: 10.1016/S1474-4422(13)70160-1
pubmed: 23948178
Langguth B, Elgoyhen AB, Schlee W (2016) Potassium channels as promising new targets for pharmacologic treatment of tinnitus: can Internet-based ‘crowd sensing’ initiated by patients speed up the transition from bench to bedside? Expert Opin Ther Targets 20(3):251–254. https://doi.org/10.1517/14728222.2016.1125884
doi: 10.1517/14728222.2016.1125884
pubmed: 26609769
Langguth B, Elgoyhen AB, Cederroth CR (2019) Therapeutic approaches to the treatment of tinnitus. Annu Rev Pharmacol Toxicol 59:291–313. https://doi.org/10.1146/annurev-pharmtox-010818-021556
doi: 10.1146/annurev-pharmtox-010818-021556
pubmed: 30044727
Lavigne P, Lavigne F, Saliba I (2016) Intratympanic corticosteroids injections: a systematic review of literature. Eur Arch Otorhinolaryngol 273(9):2271–2278. https://doi.org/10.1007/s00405-015-3689-3
doi: 10.1007/s00405-015-3689-3
pubmed: 26100030
Le Prell CG (2019) Otoprotectants: from research to clinical application. Semin Hear 40(2):162–176. https://doi.org/10.1055/s-0039-1684045
doi: 10.1055/s-0039-1684045
pubmed: 31036993
pmcid: 6486371
Lee HJ, Kim MB, Yoo SY, Park SN, Nam EC, Moon IS et al (2018) Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: a prospective, placebo-controlled, multicenter study. Laryngoscope 128(1):184–188. https://doi.org/10.1002/lary.26541
doi: 10.1002/lary.26541
pubmed: 28224644
Lefeuvre J, Chedeau J, Boulet M, Fain G, Papon JF, Nguyen Y et al (2019) Hidden hearing loss and tinnitus: utility of the high-definition audiograms in diagnosis. Clin Otolaryngol 44(6):1170–1175. https://doi.org/10.1111/coa.13435
doi: 10.1111/coa.13435
pubmed: 31535428
Lewis S, Chowdhury E, Stockdale D, Kennedy V, Guideline C (2020) Assessment and management of tinnitus: summary of NICE guidance. BMJ 368:m976. https://doi.org/10.1136/bmj.m976
doi: 10.1136/bmj.m976
pubmed: 32234748
Liberman MC, Kujawa SG (2017) Cochlear synaptopathy in acquired sensorineural hearing loss: manifestations and mechanisms. Hear Res 349:138–147. https://doi.org/10.1016/j.heares.2017.01.003
doi: 10.1016/j.heares.2017.01.003
pubmed: 28087419
pmcid: 5438769
Liberman MC, Epstein MJ, Cleveland SS, Wang H, Maison SF (2016) Toward a differential diagnosis of hidden hearing loss in humans. PLoS One 11(9):e0162726. https://doi.org/10.1371/journal.pone.0162726
doi: 10.1371/journal.pone.0162726
pubmed: 27618300
pmcid: 5019483
Liu HB, Fan JP, Lin SZ, Zhao SW, Lin Z (2011) Botox transient treatment of tinnitus due to stapedius myoclonus: case report. Clin Neurol Neurosurg 113(1):57–58. https://doi.org/10.1016/j.clineuro.2010.07.022
doi: 10.1016/j.clineuro.2010.07.022
pubmed: 20800344
Lopez-Escamez JA, Amanat S (2020) Heritability and genetics contribution to tinnitus. Otolaryngol Clin North Am. https://doi.org/10.1016/j.otc.2020.03.003
Lopez-Gonzalez MA, Moliner-Peiro F, Alfaro-Garcia J, Esteban-Ortega F (2007a) Sulpiride plus hydroxyzine decrease tinnitus perception. Auris Nasus Larynx 34(1):23–27. https://doi.org/10.1016/j.anl.2006.09.021
doi: 10.1016/j.anl.2006.09.021
pubmed: 17118597
Lopez-Gonzalez MA, Santiago AM, Esteban-Ortega F (2007b) Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. J Otolaryngol 36(4):213–219. https://doi.org/10.2310/7070.2007.0018
doi: 10.2310/7070.2007.0018
pubmed: 17942035
Lynch ED, Gu R, Pierce C, Kil J (2005) Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen. Hear Res 201(1–2):81–89. https://doi.org/10.1016/j.heares.2004.08.002
doi: 10.1016/j.heares.2004.08.002
pubmed: 15721563
Malgrange B, Varela-Nieto I, de Medina P, Paillasse MR (2015) Targeting cholesterol homeostasis to fight hearing loss: a new perspective. Front Aging Neurosci 7:3. https://doi.org/10.3389/fnagi.2015.00003
doi: 10.3389/fnagi.2015.00003
pubmed: 25688206
pmcid: 4310297
Mardini MK (1987) Ear-clicking “tinnitus” responding to carbamazepine. N Engl J Med 317(24):1542. https://doi.org/10.1056/nejm198712103172418
doi: 10.1056/nejm198712103172418
pubmed: 3683492
Mihail RC, Crowley JM, Walden BE, Fishburne J, Reinwall JE, Zajtchuk JT (1988) The tricyclic trimipramine in the treatment of subjective tinnitus. Ann Otol Rhinol Laryngol 97(2 Pt 1):120–123. https://doi.org/10.1177/000348948809700204
doi: 10.1177/000348948809700204
pubmed: 3355041
Morgan P, Brown DG, Lennard S, Anderton MJ, Barrett JC, Eriksson U et al (2018) Impact of a five-dimensional framework on R&D productivity at AstraZeneca. Nat Rev Drug Discov 17(3):167–181. https://doi.org/10.1038/nrd.2017.244
doi: 10.1038/nrd.2017.244
pubmed: 29348681
Paul BT, Bruce IC, Roberts LE (2017) Evidence that hidden hearing loss underlies amplitude modulation encoding deficits in individuals with and without tinnitus. Hear Res 344:170–182. https://doi.org/10.1016/j.heares.2016.11.010
doi: 10.1016/j.heares.2016.11.010
pubmed: 27888040
Person OC, Puga ME, da Silva EM, Torloni MR (2016) Zinc supplementation for tinnitus. Cochrane Database Syst Rev 11:CD009832. https://doi.org/10.1002/14651858.CD009832.pub2
doi: 10.1002/14651858.CD009832.pub2
pubmed: 27879981
Piccirillo JF, Finnell J, Vlahiotis A, Chole RA, Spitznagel E Jr (2007) Relief of idiopathic subjective tinnitus: is gabapentin effective? Arch Otolaryngol Head Neck Surg 133(4):390–397. https://doi.org/10.1001/archotol.133.4.390
doi: 10.1001/archotol.133.4.390
pubmed: 17438255
Prayuenyong P, Kasbekar AV, Baguley DM (2020) The efficacy of statins as otoprotective agents: a systematic review. Clin Otolaryngol 45(1):21–31. https://doi.org/10.1111/coa.13457
doi: 10.1111/coa.13457
pubmed: 31602810
Puel JL (1995) Chemical synaptic transmission in the cochlea. Prog Neurobiol 47(6):449–476. https://doi.org/10.1016/0301-0082(95)00028-3
doi: 10.1016/0301-0082(95)00028-3
pubmed: 8787031
Puel JL, Ruel J, Guitton M, Wang J, Pujol R (2002) The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies. Audiol Neurootol 7(1):49–54. https://doi.org/10.1159/000046864
doi: 10.1159/000046864
pubmed: 11914527
Radziwon KH, Hayes SH, Sheppard AM, Ding D, Salvi R (2016) Drug-induced tinnitus. In: Baguley D (ed) Tinnitus – clinical and research perspectives. Plural Publishing, San Diego
Reynard P, Ionescu E, Karkas A, Ltaeif-Boudrigua A, Thai-Van H (2019) Unilateral cochleovestibular nerve compression syndrome in a patient with bilateral IAC osteoma. Eur Ann Otorhinolaryngol Head Neck Dis 137(3):213–216. https://doi.org/10.1016/j.anorl.2019.12.004
doi: 10.1016/j.anorl.2019.12.004
pubmed: 31866273
Robinson SK, Viirre ES, Bailey KA, Gerke MA, Harris JP, Stein MB (2005) Randomized placebo-controlled trial of a selective serotonin reuptake inhibitor in the treatment of nondepressed tinnitus subjects. Psychosom Med 67(6):981–988. https://doi.org/10.1097/01.psy.0000188479.04891.74
doi: 10.1097/01.psy.0000188479.04891.74
pubmed: 16314604
Rosenhall U, Skoog B, Muhr P (2019) Treatment of military acoustic accidents with N-acetyl-L-cysteine (NAC). Int J Audiol 58(3):151–157. https://doi.org/10.1080/14992027.2018.1543961
doi: 10.1080/14992027.2018.1543961
pubmed: 30653365
Rybak LP (1993) Ototoxicity of loop diuretics. Otolaryngol Clin N Am 26(5):829–844. https://www.ncbi.nlm.nih.gov/pubmed/8233492
doi: 10.1016/S0030-6665(20)30770-2
Salehi PP, Kasle D, Torabi SJ, Michaelides E, Hildrew DM (2019) The etiology, pathogeneses, and treatment of objective tinnitus: unique case series and literature review. Am J Otolaryngol 40(4):594–597. https://doi.org/10.1016/j.amjoto.2019.03.017
doi: 10.1016/j.amjoto.2019.03.017
pubmed: 30981445
Santos N, Ferreira RS, Santos ACD (2020) Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents. Food Chem Toxicol 136:111079. https://doi.org/10.1016/j.fct.2019.111079
doi: 10.1016/j.fct.2019.111079
pubmed: 31891754
Sarafraz Z, Ahmadi A, Daneshi A (2018) Transtympanic injections of N-acetylcysteine and dexamethasone for prevention of cisplatin-induced ototoxicity: double blind randomized clinical trial. Int Tinnitus J 22(1):40–45. https://doi.org/10.5935/0946-5448.20180007
doi: 10.5935/0946-5448.20180007
pubmed: 29993216
Seligmann H, Podoshin L, Ben-David J, Fradis M, Goldsher M (1996) Drug-induced tinnitus and other hearing disorders. Drug Saf 14(3):198–212. https://doi.org/10.2165/00002018-199614030-00006
doi: 10.2165/00002018-199614030-00006
pubmed: 8934581
Sendowski I (2006) Magnesium therapy in acoustic trauma. Magnes Res 19(4):244–254. https://www.ncbi.nlm.nih.gov/pubmed/17402292
pubmed: 17402292
Sharma DK, Kaur S, Singh J, Kaur I (2012) Role of acamprosate in sensorineural tinnitus. Indian J Pharmacol 44(1):93–96. https://doi.org/10.4103/0253-7613.91876
doi: 10.4103/0253-7613.91876
pubmed: 22345878
pmcid: 3271548
Sheth S, Mukherjea D, Rybak LP, Ramkumar V (2017) Mechanisms of cisplatin-induced ototoxicity and otoprotection. Front Cell Neurosci 11:338. https://doi.org/10.3389/fncel.2017.00338
doi: 10.3389/fncel.2017.00338
pubmed: 29163050
pmcid: 5663723
Shim HJ, Lee ES, An YH, Kim DH (2017) Comparison of long-term outcome of intratympanic dexamethasone therapy between acute noise-induced tinnitus and acute idiopathic tinnitus. J Int Adv Otol 13(1):53–60. https://doi.org/10.5152/iao.2016.2632
doi: 10.5152/iao.2016.2632
pubmed: 28084998
Shore SE, Wu C (2019) Mechanisms of noise-induced tinnitus: insights from cellular studies. Neuron 103(1):8–20. https://doi.org/10.1016/j.neuron.2019.05.008
doi: 10.1016/j.neuron.2019.05.008
pubmed: 31271756
pmcid: 6613804
Shore SE, Roberts LE, Langguth B (2016) Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment. Nat Rev Neurol 12(3):150–160. https://doi.org/10.1038/nrneurol.2016.12
doi: 10.1038/nrneurol.2016.12
pubmed: 26868680
pmcid: 4895692
Simpson JJ, Gilbert AM, Weiner GM, Davies WE (1999) The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus. Am J Otol 20(5):627–631. https://www.ncbi.nlm.nih.gov/pubmed/10503585
pubmed: 10503585
Sinclair CF, Gurey LE, Blitzer A (2014) Palatal myoclonus: algorithm for management with botulinum toxin based on clinical disease characteristics. Laryngoscope 124(5):1164–1169. https://doi.org/10.1002/lary.23485
doi: 10.1002/lary.23485
pubmed: 24668771
Slengerik-Hansen J, Ovesen T (2016) Botulinum toxin treatment of objective tinnitus because of essential palatal tremor: a systematic review. Otol Neurotol 37(7):820–828. https://doi.org/10.1097/MAO.0000000000001090
doi: 10.1097/MAO.0000000000001090
pubmed: 27273401
Staecker H, Morelock M, Kramer T, Chrbolka P, Ahn JH, Meyer T (2017) Safety of repeated-dose intratympanic injections with AM-101 in acute inner ear tinnitus. Otolaryngol Head Neck Surg 157(3):478–487. https://doi.org/10.1177/0194599817711378
doi: 10.1177/0194599817711378
pubmed: 28608739
pmcid: 5673013
Suckfull M, Althaus M, Ellers-Lenz B, Gebauer A, Gortelmeyer R, Jastreboff PJ et al (2011) A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. BMC Ear Nose Throat Disord 11:1. https://doi.org/10.1186/1472-6815-11-1
doi: 10.1186/1472-6815-11-1
pubmed: 21223542
pmcid: 3031239
Sullivan M, Katon W, Russo J, Dobie R, Sakai C (1993) A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. Arch Intern Med 153(19):2251–2259. https://www.ncbi.nlm.nih.gov/pubmed/8215728
doi: 10.1001/archinte.1993.00410190091011
Sziklai I, Szilvassy J, Szilvassy Z (2011) Tinnitus control by dopamine agonist pramipexole in presbycusis patients: a randomized, placebo-controlled, double-blind study. Laryngoscope 121(4):888–893. https://doi.org/10.1002/lary.21461
doi: 10.1002/lary.21461
pubmed: 21433025
Tabuchi K, Nishimura B, Nakamagoe M, Hayashi K, Nakayama M, Hara A (2011) Ototoxicity: mechanisms of cochlear impairment and its prevention. Curr Med Chem 18(31):4866–4871. https://doi.org/10.2174/092986711797535254
doi: 10.2174/092986711797535254
pubmed: 21919841
Taha A, Shlamkovitch N, Abu-Eta R, Yeheskeli E, Muallem-Kalmovich L, Gavriel H et al (2019) High dose of intratympanic steroids for sudden sensorineural hearing loss salvage. Otol Neurotol 40(9):1134–1138. https://doi.org/10.1097/MAO.0000000000002386
doi: 10.1097/MAO.0000000000002386
pubmed: 31498293
Tillinger JA, Gupta C, Ila K, Ahmed J, Mittal J, Van De Water TR et al (2018) l-N-acetylcysteine protects outer hair cells against TNFalpha initiated ototoxicity in vitro. Acta Otolaryngol 138(8):676–684. https://doi.org/10.1080/00016489.2018.1440086
doi: 10.1080/00016489.2018.1440086
pubmed: 29513056
Trellakis S, Lautermann J, Lehnerdt G (2007) Lidocaine: neurobiological targets and effects on the auditory system. Prog Brain Res 166:303–322. https://doi.org/10.1016/S0079-6123(07)66028-2
doi: 10.1016/S0079-6123(07)66028-2
pubmed: 17956794
Tunkel DE, Bauer CA, Sun GH, Rosenfeld RM, Chandrasekhar SS, Cunningham ER Jr et al (2014) Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg 151(2 Suppl):S1–S40. https://doi.org/10.1177/0194599814545325
doi: 10.1177/0194599814545325
pubmed: 25273878
Tyler RS (2012) Patient preferences and willingness to pay for tinnitus treatments. J Am Acad Audiol 23(2):115–125. https://doi.org/10.3766/jaaa.23.2.6
doi: 10.3766/jaaa.23.2.6
pubmed: 22353680
van As JW, van den Berg H, van Dalen EC (2018) Different infusion durations for preventing platinum-induced hearing loss in children with cancer. Cochrane Database Syst Rev 7:CD010885. https://doi.org/10.1002/14651858.CD010885.pub4
doi: 10.1002/14651858.CD010885.pub4
pubmed: 29975402
van As JW, van den Berg H, van Dalen EC (2019) Medical interventions for the prevention of platinum-induced hearing loss in children with cancer. Cochrane Database Syst Rev 5:CD009219. https://doi.org/10.1002/14651858.CD009219.pub5
doi: 10.1002/14651858.CD009219.pub5
pubmed: 31063591
van de Heyning P, Muehlmeier G, Cox T, Lisowska G, Maier H, Morawski K et al (2014) Efficacy and safety of AM-101 in the treatment of acute inner ear tinnitus--a double-blind, randomized, placebo-controlled phase II study. Otol Neurotol 35(4):589–597. https://doi.org/10.1097/MAO.0000000000000268
doi: 10.1097/MAO.0000000000000268
pubmed: 24603353
pmcid: 3966923
von der Behrens W (2014) Animal models of subjective tinnitus. Neural Plast 2014:741452. https://doi.org/10.1155/2014/741452
doi: 10.1155/2014/741452
pubmed: 24829805
pmcid: 4009209
Waissbluth S (2020) Clinical trials evaluating transtympanic otoprotectants for cisplatin-induced ototoxicity: what do we know so far? Eur Arch Otorhinolaryngol. https://doi.org/10.1007/s00405-020-06003-w
Wegner I, Hall DA, Smit AL, McFerran D, Stegeman I (2018) Betahistine for tinnitus. Cochrane Database Syst Rev 12:CD013093. https://doi.org/10.1002/14651858.CD013093.pub2
doi: 10.1002/14651858.CD013093.pub2
pubmed: 30908589
Westerberg BD, Roberson JB Jr, Stach BA (1996) A double-blind placebo-controlled trial of baclofen in the treatment of tinnitus. Am J Otol 17(6):896–903. https://www.ncbi.nlm.nih.gov/pubmed/8915419
pubmed: 8915419
Xiong B, Liu Z, Liu Q, Peng Y, Wu H, Lin Y et al (2019) Missed hearing loss in tinnitus patients with normal audiograms. Hear Res 384:107826. https://doi.org/10.1016/j.heares.2019.107826
doi: 10.1016/j.heares.2019.107826
pubmed: 31683074
Yang S, Weiner BD, Zhang LS, Cho SJ, Bao S (2011) Homeostatic plasticity drives tinnitus perception in an animal model. Proc Natl Acad Sci U S A 108(36):14974–14979. https://doi.org/10.1073/pnas.1107998108
doi: 10.1073/pnas.1107998108
pubmed: 21896771
pmcid: 3169130
Yeh CW, Tseng LH, Yang CH, Hwang CF (2019) Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: a clinical trial. Biomed J 42(1):46–52. https://doi.org/10.1016/j.bj.2018.10.009
doi: 10.1016/j.bj.2018.10.009
pubmed: 30987704
pmcid: 6468114
Yoo J, Hamilton SJ, Angel D, Fung K, Franklin J, Parnes LS et al (2014) Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients. Laryngoscope 124(3):E87–E94. https://doi.org/10.1002/lary.24360
doi: 10.1002/lary.24360
pubmed: 23946126
Zeman F, Koller M, Langguth B, Landgrebe M, Tinnitus Research Initiative database study group (2014) Which tinnitus-related aspects are relevant for quality of life and depression: results from a large international multicentre sample. Health Qual Life Outcomes 12:7. https://doi.org/10.1186/1477-7525-12-7
doi: 10.1186/1477-7525-12-7
pubmed: 24422941
pmcid: 3896823
Zenner HP, Delb W, Kroner-Herwig B, Jager B, Peroz I, Hesse G et al (2017) A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus. Eur Arch Otorhinolaryngol 274(5):2079–2091. https://doi.org/10.1007/s00405-016-4401-y
doi: 10.1007/s00405-016-4401-y
pubmed: 27995315
Zhao H, Dong H, Cheng Y, Ma Y, Lin P, Zhong S et al (2015) Multi-center study on the treatment of sudden deafness accompanied with tinnitus. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 50(6):453–457. https://www.ncbi.nlm.nih.gov/pubmed/26695794
pubmed: 26695794
Zhu C, Gausterer JC, Schopper H, Nieratschker M, Saidov N, Ahmadi N et al (2018) Evaluation of sustained-release steroid hydrogels in a guinea pig model for noise-induced hearing loss. Audiol Neurootol 23(2):73–81. https://doi.org/10.1159/000487662
doi: 10.1159/000487662
pubmed: 30092561
Zoger S, Svedlund J, Holgers KM (2006) The effects of sertraline on severe tinnitus suffering--a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 26(1):32–39. https://doi.org/10.1097/01.jcp.0000195111.86650.19
doi: 10.1097/01.jcp.0000195111.86650.19
pubmed: 16415703