Final 5-year findings from the phase 3 HELIOS study of ibrutinib plus bendamustine and rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma.

Adenine / analogs & derivatives Antineoplastic Combined Chemotherapy Protocols / adverse effects Bendamustine Hydrochloride / therapeutic use Humans Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy Piperidines Rituximab / therapeutic use
5-year follow-up HELIOS phase 3 trial Ibrutinib overall survival relapsed chronic lymphocytic leukemia

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 9 8 2020
medline: 28 4 2021
entrez: 9 8 2020
Statut: ppublish

Résumé

We report final analysis outcomes from the phase 3 HELIOS study (NCT01611090). Patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma without deletion 17p (

Identifiants

DOI: 10.1080/10428194.2020.1795159 PMID: 32762271 PMC: PMC9094431
pubmed: 32762271
doi: 10.1080/10428194.2020.1795159
pmc: PMC9094431
mid: NIHMS1784920
doi:

Substances chimiques

Piperidines 0
ibrutinib 1X70OSD4VX
Rituximab 4F4X42SYQ6
Bendamustine Hydrochloride 981Y8SX18M
Adenine JAC85A2161

Banques de données

ClinicalTrials.gov
['NCT01611090']

Types de publication

Clinical Trial, Phase III Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

3188-3197

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States

Références

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Auteurs

Graeme A M Fraser (GAM)

Juravinski Cancer Centre, McMaster University, Hamilton, Canada.

Asher Chanan-Khan (A)

Division of Hematology, Mayo Clinic Cancer Center, Jacksonville, FL, USA.

Fatih Demirkan (F)

Division of Hematology, Dokuz Eylul University, Izmir, Turkey.

Rodrigo Santucci Silva (R)

IEP São Lucas/Hemomed Oncologia e Hematologia, São Paulo, Brazil.

Sebastian Grosicki (S)

Department of Hematology and Cancer Prevention, School of Public Health, Silesian Medical University, Katowice, Poland.

Ann Janssens (A)

Universitaire Ziekenhuizen Leuven, Leuven, Belgium.

Jiri Mayer (J)

Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Jihlavska, Brno, Czech Republic.

Nancy L Bartlett (NL)

Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0001-8470-394X

Marie-Sarah Dilhuydy (MS)

Hopital Haut Leveque, Bordeaux, France.

Javier Loscertales (J)

Hematology Department, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain.

Abraham Avigdor (A)

Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, University of Tel-Aviv, Tel-Aviv, Israel.

Simon Rule (S)

Department of Haematology, University of Plymouth Medical School, Plymouth, UK.
ORCID: 0000-0001-8937-6351

Olga Samoilova (O)

Nizhny Novogorod Regional Clinical Hospital, Nizhny Novogorod, Russia.

Miguel A Pavlovsky (MA)

Department of Hematology, Fundaleu, Buenos Aires, Argentina.

Andre Goy (A)

John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA.

Anthony Mato (A)

Memorial Sloan-Kettering Cancer Center, NY, USA.

Michael Hallek (M)

Department I of Internal Medicine and German CLL Study Group, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.

Mariya Salman (M)

Janssen Research & Development, Raritan, NJ, USA.

Monelle Tamegnon (M)

Janssen Research & Development, Raritan, NJ, USA.

Steven Sun (S)

Janssen Research & Development, Raritan, NJ, USA.

Anne Connor (A)

Janssen Research & Development, Spring House, PA, USA.

Kerri Nottage (K)

Janssen Research & Development, Raritan, NJ, USA.

Natasha Schuier (N)

Janssen-Cilag, Neuss, Germany.

Sriram Balasubramanian (S)

Janssen Research & Development, Spring House, PA, USA.

Angela Howes (A)

Janssen Research & Development, High Wycombe, UK.

Paula Cramer (P)

Department I of Internal Medicine and German CLL Study Group, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adénine › Final 5-year findings from the phase 3 HELIOS...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › Final 5-year findings from the phase 3 HELIOS...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Chlorhydrate de bendamustine › Final 5-year findings from the phase 3 HELIOS...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Final 5-year findings from the phase 3 HELIOS...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie chronique lymphocytaire à cellules B › Final 5-year findings from the phase 3 HELIOS...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Final 5-year findings from the phase 3 HELIOS...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux d'origine murine › Rituximab › Final 5-year findings from the phase 3 HELIOS...