Nesfatin-1 attenuates injury in a rat model of myocardial infarction by targeting autophagy, inflammation, and apoptosis.
Myocardial infarction
apoptosis
autophagy
nesfatin-1
oxidative stress
Journal
Archives of physiology and biochemistry
ISSN: 1744-4160
Titre abrégé: Arch Physiol Biochem
Pays: England
ID NLM: 9510153
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pubmed:
9
8
2020
medline:
7
2
2023
entrez:
9
8
2020
Statut:
ppublish
Résumé
Nesfatin-1 plays an important role in the modulation of heart performance. However, it remains unclear how nesfatin-1 contributes to cell survival in acute myocardial infarction (MI). A rat model of MI was established via ligation of left anterior descending coronary artery (LAD) for 30 min and 20 µg/kg concentration of nesfatin-1 was intraperitoneally infused prior to reperfusion. At 24 h after reperfusion, oxidative stress markers, the expression of caspase3, beclin-1, pro-inflammatory cytokines, and the mRNA levels of Bax and Bcl-2 were evaluated. Results showed that nesfatin-1 markedly restored GSH content and SOD activity as well as reduced MDA levels compared to only the MI group (
Identifiants
pubmed: 32762481
doi: 10.1080/13813455.2020.1802486
doi:
Substances chimiques
bcl-2-Associated X Protein
0
NUCB2 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM