Longitudinal analysis of subtype C envelope tropism for memory CD4

Adult CD4-Positive T-Lymphocytes / immunology Female Genetic Variation HIV Infections / immunology HIV-1 / classification Humans Immunologic Memory Longitudinal Studies Phylogeny Receptors, HIV / metabolism T-Lymphocyte Subsets / immunology Viral Tropism env Gene Products, Human Immunodeficiency Virus / genetics
CD4+ T cells Cellular tropism Coreceptor usage Envelope Subtype C HIV-1

Journal

Retrovirology
ISSN: 1742-4690
Titre abrégé: Retrovirology
Pays: England
ID NLM: 101216893

Informations de publication

Date de publication:
06 08 2020
Historique:
received: 02 06 2020
accepted: 27 07 2020
entrez: 9 8 2020
pubmed: 9 8 2020
medline: 25 6 2021
Statut: epublish

Résumé

HIV-1 infects a wide range of CD4 A total of 50 C-HIV envs were cloned and screened for functionality in pseudovirus infection assays. Phylogenetic and variable region characteristic analysis demonstrated evolution in envs between time points. We found 45 pseudoviruses were functional and all used CCR5 to mediate entry into NP2/CD4/CCR5 cells. In vitro infection assays showed transitional memory (TM) and effector memory (EM) CD4 CD4

Sections du résumé

BACKGROUND
HIV-1 infects a wide range of CD4
RESULTS
A total of 50 C-HIV envs were cloned and screened for functionality in pseudovirus infection assays. Phylogenetic and variable region characteristic analysis demonstrated evolution in envs between time points. We found 45 pseudoviruses were functional and all used CCR5 to mediate entry into NP2/CD4/CCR5 cells. In vitro infection assays showed transitional memory (TM) and effector memory (EM) CD4
CONCLUSIONS
CD4

Identifiants

DOI: 10.1186/s12977-020-00532-2 PMID: 32762760 PMC: PMC7409430
pubmed: 32762760
doi: 10.1186/s12977-020-00532-2
pii: 10.1186/s12977-020-00532-2
pmc: PMC7409430
doi:

Substances chimiques

Receptors, HIV 0
env Gene Products, Human Immunodeficiency Virus 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

24

Subventions

Organisme : NIMHD NIH HHS
ID : L60 MD003100
Pays : United States

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Auteurs

Matthew J Gartner (MJ)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.

Paul R Gorry (PR)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.

Carolin Tumpach (C)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.

Jingling Zhou (J)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.

Ashanti Dantanarayana (A)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.

J Judy Chang (JJ)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.

Thomas A Angelovich (TA)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Life Sciences, Burnet Institute, Melbourne, VIC, Australia.

Paula Ellenberg (P)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.

Annemarie E Laumaea (AE)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.

Molati Nonyane (M)

Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.

Penny L Moore (PL)

Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

Sharon R Lewin (SR)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, Australia.

Melissa J Churchill (MJ)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.

Jacqueline K Flynn (JK)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia. Jacqueline.Flynn@unimelb.edu.au.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia. Jacqueline.Flynn@unimelb.edu.au.
School of Clinical Sciences, Monash University, Melbourne, VIC, Australia. Jacqueline.Flynn@unimelb.edu.au.

Michael Roche (M)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia. Michael.roche@rmit.edu.au.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia. Michael.roche@rmit.edu.au.
ORCID: 0000-0001-8819-0096

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Tropisme viral › Longitudinal analysis of subtype C envelope...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Produits du gène env › Produits du gène env du virus de l'immunodéficience humaine › Longitudinal analysis of subtype C envelope...