Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front.

B7-H1 Antigen / immunology Biomarkers, Tumor / immunology CD4-Positive T-Lymphocytes / immunology Cell Line, Tumor Colorectal Neoplasms / immunology Female Humans Immunotherapy / methods Male Neoplasm Invasiveness / immunology Tumor Microenvironment / immunology
CODEX FFPE antitumoral immunity cellular neighborhoods colorectal cancer immune checkpoints immune tumor microenvironment multiplexed imaging tertiary lymphoid structures tissue architecture

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
03 09 2020
Historique:
received: 29 07 2019
revised: 22 04 2020
accepted: 08 07 2020
pubmed: 9 8 2020
medline: 8 5 2021
entrez: 9 8 2020
Statut: ppublish

Résumé

Antitumoral immunity requires organized, spatially nuanced interactions between components of the immune tumor microenvironment (iTME). Understanding this coordinated behavior in effective versus ineffective tumor control will advance immunotherapies. We re-engineered co-detection by indexing (CODEX) for paraffin-embedded tissue microarrays, enabling simultaneous profiling of 140 tissue regions from 35 advanced-stage colorectal cancer (CRC) patients with 56 protein markers. We identified nine conserved, distinct cellular neighborhoods (CNs)-a collection of components characteristic of the CRC iTME. Enrichment of PD-1

Identifiants

DOI: 10.1016/j.cell.2020.07.005 PMID: 32763154 PMC: PMC7479520
pubmed: 32763154
pii: S0092-8674(20)30870-9
doi: 10.1016/j.cell.2020.07.005
pmc: PMC7479520
pii:
doi:

Substances chimiques

B7-H1 Antigen 0
Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1341-1359.e19

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007290
Pays : United States
Organisme : NIDDK NIH HHS
ID : UG3 DK114937
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100627
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120724
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI101984
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG010426
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA212231
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI140498
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135976
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131374
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057229
Pays : United States
Organisme : NCI NIH HHS
ID : U2C CA233238
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA233203
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL108797
Pays : United States
Organisme : NCI NIH HHS
ID : U2C CA233195
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128173
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA183692
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007422
Pays : United States
Organisme : Cancer Research UK
ID : C27165/A29073
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests G.P.N. has received research grants from Pfizer, Vaxart, Celgene, and Juno Therapeutics during the course of this work. G.P.N., Y.G., and N.S. have equity in and are scientific advisory board members of Akoya Biosciences. C.M.S. is a scientific advisor to Enable Medicine. Akoya Biosciences makes reagents and instruments that are dependent on licenses from Stanford University. Stanford University has been granted US patent 9909167, which covers some aspects of the technology described in this paper.

Auteurs

Christian M Schürch (CM)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: christian.m.schuerch@gmail.com.

Salil S Bhate (SS)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.

Graham L Barlow (GL)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Darci J Phillips (DJ)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Luca Noti (L)

Institute of Pathology, University of Bern, 3008 Bern, Switzerland.

Inti Zlobec (I)

Institute of Pathology, University of Bern, 3008 Bern, Switzerland.

Pauline Chu (P)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Sarah Black (S)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Janos Demeter (J)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

David R McIlwain (DR)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Shigemi Kinoshita (S)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nikolay Samusik (N)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Yury Goltsev (Y)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Garry P Nolan (GP)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: gnolan@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › Coordinated Cellular Neighborhoods Orchestrate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Coordinated Cellular Neighborhoods Orchestrate...