Marijuana use and pneumonia risk in a cohort of HIV-infected and HIV-uninfected men.
Adolescent
Adult
Aged
Antiretroviral Therapy, Highly Active
Cohort Studies
HIV Infections
/ complications
HIV Seronegativity
Homosexuality, Male
/ statistics & numerical data
Humans
Longitudinal Studies
Male
Marijuana Smoking
/ epidemiology
Marijuana Use
/ epidemiology
Middle Aged
Pneumonia
/ epidemiology
Prevalence
Proportional Hazards Models
Risk Factors
United States
/ epidemiology
Young Adult
HIV
Marijuana
Pneumonia
Journal
Annals of epidemiology
ISSN: 1873-2585
Titre abrégé: Ann Epidemiol
Pays: United States
ID NLM: 9100013
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
27
11
2019
revised:
09
07
2020
accepted:
28
07
2020
pubmed:
9
8
2020
medline:
16
1
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
The prevalence of marijuana use is increasing in the United States. Marijuana smoking has been shown to impair the microbicidal activity of alveolar macrophages and decrease the number of ciliated epithelial cells in the bronchi with a parallel increase in the number of mucus-secreting surface epithelial cells, which may increase the risk of pneumonia. However, it remains unclear whether there is an association between smoking marijuana and pneumonia. Using data from the Multicenter AIDS Cohort Study (MACS), a long-term observational cohort study of men who have sex with men in the United States, we used Cox proportional hazards models to estimate the risk of pneumonia among HIV-infected (n = 2784) and HIV-uninfected (n = 2665) men from 1984 to 2013, adjusted for time-varying and fixed baseline covariates. Weekly or daily marijuana use was not significantly associated with increased risk of pneumonia among HIV-uninfected men (adjusted hazard ratio; 95% confidence limits: 0.83, 0.56-1.23). In the disaggregated dose-response analysis, daily use (0.68, 0.34-1.35) was associated with a lower point estimate than weekly use [0.99, 0.79-1.25]. Marijuana smoking was not associated with a significant increase in risk of pneumonia among HIV-infected or HIV-uninfected men.
Sections du résumé
BACKGROUND
The prevalence of marijuana use is increasing in the United States. Marijuana smoking has been shown to impair the microbicidal activity of alveolar macrophages and decrease the number of ciliated epithelial cells in the bronchi with a parallel increase in the number of mucus-secreting surface epithelial cells, which may increase the risk of pneumonia. However, it remains unclear whether there is an association between smoking marijuana and pneumonia.
METHODS
Using data from the Multicenter AIDS Cohort Study (MACS), a long-term observational cohort study of men who have sex with men in the United States, we used Cox proportional hazards models to estimate the risk of pneumonia among HIV-infected (n = 2784) and HIV-uninfected (n = 2665) men from 1984 to 2013, adjusted for time-varying and fixed baseline covariates.
RESULTS
Weekly or daily marijuana use was not significantly associated with increased risk of pneumonia among HIV-uninfected men (adjusted hazard ratio; 95% confidence limits: 0.83, 0.56-1.23). In the disaggregated dose-response analysis, daily use (0.68, 0.34-1.35) was associated with a lower point estimate than weekly use [0.99, 0.79-1.25].
CONCLUSION
Marijuana smoking was not associated with a significant increase in risk of pneumonia among HIV-infected or HIV-uninfected men.
Identifiants
pubmed: 32763342
pii: S1047-2797(20)30278-7
doi: 10.1016/j.annepidem.2020.07.018
pmc: PMC7725997
mid: NIHMS1640752
pii:
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-70.e2Subventions
Organisme : NIAID NIH HHS
ID : U01 AI035042
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146333
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007266
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035041
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI035043
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035040
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146240
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035039
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007481
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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