The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin.

Acetylcysteine Administration, Oral Animals Biological Availability Curcumin / pharmacokinetics Drug Carriers Intestinal Absorption Nanoparticles Rats
Bovine serum albumin nanoparticle Curcumin Gastrointestinal tract N-acetylcysteine Oral bioavailability

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Nov 2020
Historique:
received: 07 05 2020
revised: 22 07 2020
accepted: 04 08 2020
pubmed: 9 8 2020
medline: 27 5 2021
entrez: 9 8 2020
Statut: ppublish

Résumé

To solve the low oral bioavailability of curcumin (CUR) due to the limits imposed by gastrointestinal (GI) barrier, we constructed a nano delivery system to evaluate the effect of N-acetyl-L-cysteine (NAC) on intestinal absorption and oral bioavailability of CUR. CUR was first encapsulated in bovine serum albumin nanoparticles (CUR-BSA-NPs), and then was further modified by NAC (CUR-NBSA-NPs). In situ single-pass intestinal perfusion assay demonstrated that CUR-NBSA-NPs displayed excellent permeation and absorption rates in GI tract. Additionally, the distribution study in GI tract revealed that more NBSA-NPs were absorbed by intestinal segments compared to the BSA nanoparticles. Plasma concentration-time curves in rats showed that AUC

Identifiants

DOI: 10.1016/j.ejps.2020.105506 PMID: 32763460
pubmed: 32763460
pii: S0928-0987(20)30295-5
doi: 10.1016/j.ejps.2020.105506
pii:
doi:

Substances chimiques

Drug Carriers 0
Curcumin IT942ZTH98
Acetylcysteine WYQ7N0BPYC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105506

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Shanshan Zhang (S)

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Sajid Asghar (S)

Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.

Feng Yu (F)

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Ziyi Hu (Z)

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Qineng Ping (Q)

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Zhipeng Chen (Z)

Department of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: czpcpu2000@hotmail.com.

Feng Shao (F)

Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: jsphshaofeng@hotmail.com.

Yanyu Xiao (Y)

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpuyanyuxiao@163.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Acétylcystéine › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Eucaryotes › Animaux › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Absorption gastro-intestinale › Absorption intestinale › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › The enhancement of N-acetylcysteine on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The enhancement of N-acetylcysteine on...