Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis.
COVID-19
Clinical characteristics
Comorbidities
Imaging features
Laboratory findings
Meta-analysis
Outcomes
SARS-CoV-2
Systematic review
Treatment
Journal
Travel medicine and infectious disease
ISSN: 1873-0442
Titre abrégé: Travel Med Infect Dis
Pays: Netherlands
ID NLM: 101230758
Informations de publication
Date de publication:
Historique:
received:
14
05
2020
revised:
09
07
2020
accepted:
27
07
2020
pubmed:
9
8
2020
medline:
30
10
2020
entrez:
9
8
2020
Statut:
ppublish
Résumé
Since December 2019, a novel coronavirus (SARS-CoV-2) has triggered a world-wide pandemic with an enormous medical and societal-economic toll. Thus, our aim was to gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19). EMBASE, PubMed/Medline, Scopus, and Web of Science were searched for studies published in any language between December 1st, 2019 and March 28th, 2020. Original studies were included if the exposure of interest was an infection with SARS-CoV-2 or confirmed COVID-19. The primary outcome was the risk ratio of comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatments, outcomes, and complications associated with COVID-19 morbidity and mortality. We performed random-effects pairwise meta-analyses for proportions and relative risks, I 148 studies met the inclusion criteria for the systematic review and meta-analysis with 12'149 patients (5'739 female) and a median age of 47.0 [35.0-64.6] years. 617 patients died from COVID-19 and its complication. 297 patients were reported as asymptomatic. Older age (SMD: 1.25 [0.78-1.72]; p < 0.001), being male (RR = 1.32 [1.13-1.54], p = 0.005) and pre-existing comorbidity (RR = 1.69 [1.48-1.94]; p < 0.001) were identified as risk factors of in-hospital mortality. The heterogeneity between studies varied substantially (I Our meta-analyses revealed important risk factors that are associated with severity and mortality of COVID-19.
Identifiants
pubmed: 32763496
pii: S1477-8939(20)30321-5
doi: 10.1016/j.tmaid.2020.101825
pmc: PMC7402237
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101825Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
World J Pediatr. 2020 Jun;16(3):267-270
pubmed: 32180140
Chest. 2000 Aug;118(2):503-8
pubmed: 10936147
QJM. 2020 Jul 1;113(7):474-481
pubmed: 32181807
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Euro Surveill. 2020 Feb;25(6):
pubmed: 32070465
Clin Infect Dis. 2020 Jul 28;71(15):706-712
pubmed: 32109279
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
J Gen Intern Med. 2020 May;35(5):1545-1549
pubmed: 32133578
Zhonghua Er Ke Za Zhi. 2020 Feb 11;58(0):E006
pubmed: 32043842
Int J Infect Dis. 2020 May;94:81-87
pubmed: 32205284
Eur J Nucl Med Mol Imaging. 2020 May;47(5):1275-1280
pubmed: 32107577
Stat Med. 2019 Mar 15;38(6):969-984
pubmed: 30460713
Ann Intern Med. 2020 May 19;172(10):699-701
pubmed: 32176272
J Epidemiol Community Health. 2017 Feb;71(2):154-161
pubmed: 27660401
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Eur Heart J. 2020 May 14;41(19):1798-1800
pubmed: 32186331
Can Assoc Radiol J. 2020 May;71(2):195-200
pubmed: 32129670
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Int J Infect Dis. 2020 Apr;93:264-267
pubmed: 32114193
Lancet. 2020 Feb 15;395(10223):470-473
pubmed: 31986257
Lancet. 2020 Feb 29;395(10225):734
pubmed: 32061312
Rev Med Virol. 2020 May;30(3):e2103
pubmed: 32175637
Curr Med Sci. 2020 Apr;40(2):275-280
pubmed: 32207032
Osong Public Health Res Perspect. 2020 Feb;11(1):8-14
pubmed: 32149037
Lancet Infect Dis. 2020 Apr;20(4):408-409
pubmed: 32085849
Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jul 24;48(7):567-571
pubmed: 32141280
PLoS Med. 2009 Jul 21;6(7):e1000100
pubmed: 19621070
Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S504-12
pubmed: 16237654
Emerg Infect Dis. 2020 Jun;26(6):1337-1339
pubmed: 32150527
Zhonghua Nei Ke Za Zhi. 2020 Mar 01;59(0):E003
pubmed: 32114745
Biosci Trends. 2020 Mar 16;14(1):64-68
pubmed: 32037389
Clin Infect Dis. 2020 Jul 28;71(15):853-857
pubmed: 32161941
Evid Based Ment Health. 2019 Nov;22(4):153-160
pubmed: 31563865
Int J Infect Dis. 2020 May;94:68-71
pubmed: 32179140
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Feb 17;54(0):E005
pubmed: 32064855
Eur Respir J. 2020 Apr 23;55(4):
pubmed: 32139462
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Jpn J Radiol. 2020 May;38(5):407-408
pubmed: 32189175
Eur Respir J. 2020 Apr 30;55(4):
pubmed: 32139463
J Infect. 2020 Mar 3;:
pubmed: 32142928
Zhonghua Jie He He Hu Xi Za Zhi. 2020 May 12;43(5):427-430
pubmed: 32087623
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Euro Surveill. 2020 Mar;25(9):
pubmed: 32156327
Br J Anaesth. 2020 May;124(5):e216-e218
pubmed: 32192711
Clin Infect Dis. 2020 Jul 28;71(15):769-777
pubmed: 32176772
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
J Thromb Haemost. 2020 Jul;18(7):1743-1746
pubmed: 32320517
J Immunol. 2017 May 15;198(10):4046-4053
pubmed: 28373583
JAMA. 2020 Mar 17;323(11):1092-1093
pubmed: 32031568
Zhonghua Er Ke Za Zhi. 2020 Feb 04;58(0):E002
pubmed: 32023679
JAMA. 2020 Apr 28;323(16):1612-1614
pubmed: 32191259
AJR Am J Roentgenol. 2020 Aug;215(2):338-343
pubmed: 32181672
J Infect. 2020 Apr;80(4):388-393
pubmed: 32112884
N Engl J Med. 2020 Apr 2;382(14):1370-1371
pubmed: 32163697
Balkan Med J. 2020 Mar 06;37(3):163-165
pubmed: 32157862
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):203-208
pubmed: 32164089
BMJ. 2020 Feb 19;368:m606
pubmed: 32075786
J Infect. 2020 Jul;81(1):147-178
pubmed: 32205138
J Thromb Haemost. 2020 Apr;18(4):844-847
pubmed: 32073213
Lancet. 2020 Mar 14;395(10227):846-848
pubmed: 32151325
Acad Radiol. 2020 May;27(5):609-613
pubmed: 32204990
Chin Med J (Engl). 2020 Jun 20;133(12):1487-1488
pubmed: 32149771
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):209-214
pubmed: 32164090
Lancet Child Adolesc Health. 2020 May;4(5):405-406
pubmed: 32213326
Gut. 2020 Jun;69(6):1002-1009
pubmed: 32213556
Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L493-502
pubmed: 11159033
Quant Imaging Med Surg. 2020 Feb;10(2):508-510
pubmed: 32190575
Zhonghua Bing Li Xue Za Zhi. 2020 May 8;49(5):418-423
pubmed: 32114744
Korean J Radiol. 2020 May;21(5):614-619
pubmed: 32174054
PLoS Med. 2018 Nov 1;15(11):e1002685
pubmed: 30383787
PLoS Pathog. 2010 Feb 05;6(2):e1000756
pubmed: 20140198
Lancet. 2020 Mar 7;395(10226):809-815
pubmed: 32151335
Am J Public Health. 2009 Oct;99 Suppl 2:S405-11
pubmed: 19797755
JAMA. 2020 May 12;323(18):1846-1848
pubmed: 32215581
Clin Infect Dis. 2020 Jul 28;71(15):786-792
pubmed: 32211755
Lancet Infect Dis. 2020 Apr;20(4):425-434
pubmed: 32105637
AJR Am J Roentgenol. 2020 Jul;215(1):121-126
pubmed: 32174128
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
J Infect Dis. 2020 May 11;221(11):1757-1761
pubmed: 32067043
Clin Infect Dis. 2020 Jul 28;71(15):844-846
pubmed: 32119083
Chin Med J (Engl). 2020 May 5;133(9):1015-1024
pubmed: 32004165
N Engl J Med. 2020 Mar 5;382(10):929-936
pubmed: 32004427
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Mar;22(3):211-214
pubmed: 32204755
N Engl J Med. 2020 Apr 23;382(17):1663-1665
pubmed: 32187458
World J Pediatr. 2020 Jun;16(3):251-259
pubmed: 32193831
J Infect. 2020 May;80(5):e14-e17
pubmed: 32171867
Pediatr Pulmonol. 2020 May;55(5):1169-1174
pubmed: 32134205
J Infect Dis. 2017 Oct 17;216(7):829-833
pubmed: 28973159
Fa Yi Xue Za Zhi. 2020 Feb;36(1):21-23
pubmed: 32198987
Rofo. 2020 May;192(5):476-477
pubmed: 32193883
Am J Med. 2020 Nov;133(11):1291-1292
pubmed: 32205073
J Infect. 2020 Jul;81(1):147-178
pubmed: 32209381
Clin Infect Dis. 2020 Jul 28;71(15):740-747
pubmed: 32211844
Zhonghua Xue Ye Xue Za Zhi. 2020 Apr 14;41(4):340
pubmed: 32145715
Travel Med Infect Dis. 2020 Jul - Aug;36:101606
pubmed: 32114074
Sci China Life Sci. 2020 May;63(5):706-711
pubmed: 32146694
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):634-637
pubmed: 32159317
J Infect Dis. 2020 May 11;221(11):1770-1774
pubmed: 32179910
J Infect. 2020 May;80(5):e1-e6
pubmed: 32171869
PLoS One. 2020 Mar 19;15(3):e0230548
pubmed: 32191764
J Infect. 2020 May;80(5):e7-e13
pubmed: 32171865
Chin Med J (Engl). 2020 May 5;133(9):1032-1038
pubmed: 32118640
JAMA Cardiol. 2020 Jul 1;5(7):802-810
pubmed: 32211816
J Med Virol. 2020 Sep;92(9):1549-1555
pubmed: 32196707
BMJ. 2020 Mar 23;368:m1165
pubmed: 32205334
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
J Med Virol. 2020 May;92(5):461-463
pubmed: 32073161
Emerg Infect Dis. 2020 May;26(5):1052-1054
pubmed: 32091386
Korean J Radiol. 2020 Mar;21(3):365-368
pubmed: 32056397
BMJ. 2020 Apr 2;369:m1375
pubmed: 32241884
J Microbiol Immunol Infect. 2020 Jun;53(3):499-500
pubmed: 32198004
Can J Anaesth. 2020 Jun;67(6):754-755
pubmed: 32162211
Clin Radiol. 2020 May;75(5):335-340
pubmed: 32199619
Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jun 24;48(6):450-455
pubmed: 32120458
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
J Clin Endocrinol Metab. 2016 Oct;101(10):3740-3746
pubmed: 27490920
J Infect Dis. 2020 May 11;221(11):1775-1781
pubmed: 32179908
Eur Radiol. 2020 Aug;30(8):4407-4416
pubmed: 32215691
Clin Infect Dis. 2021 Mar 1;72(5):862-864
pubmed: 32182347
Am J Emerg Med. 2012 Nov;30(9):1991-9
pubmed: 22795996
Zhonghua Er Ke Za Zhi. 2020 Mar 2;58(3):179-182
pubmed: 32135586
JAMA. 2020 Apr 21;323(15):1488-1494
pubmed: 32125362
Zhonghua Er Ke Za Zhi. 2020 Feb 16;58(0):E007
pubmed: 32061200
Int J Infect Dis. 2020 Apr;93:192-197
pubmed: 32112966
Fam Med. 2005 May;37(5):360-3
pubmed: 15883903
Clin Infect Dis. 2020 Jul 28;71(15):756-761
pubmed: 32161968
J Infect. 2020 Apr;80(4):401-406
pubmed: 32112886
Eur Respir J. 2020 Apr 23;55(4):
pubmed: 32139464
Infect Control Hosp Epidemiol. 2020 Jun;41(6):753-754
pubmed: 32188528
Gut. 2020 Jun;69(6):1143-1144
pubmed: 32139552
AJR Am J Roentgenol. 2020 May;214(5):W85-W86
pubmed: 32208010
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Zhonghua Er Ke Za Zhi. 2020 Feb 17;58(0):E009
pubmed: 32065520
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):629-633
pubmed: 32149484
Clin Imaging. 2020 Jul;63:7-9
pubmed: 32120312
Lancet. 2020 Feb 15;395(10223):473-475
pubmed: 32043983
J Infect. 2020 Jun;80(6):671-693
pubmed: 32092387
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
Radiology. 2020 Apr;295(1):20
pubmed: 32032497
Radiology. 2020 Apr;295(1):208-209
pubmed: 32031481
Radiology. 2020 Apr;295(1):21
pubmed: 32049602
Balkan Med J. 2020 Mar 26;37(4):226-228
pubmed: 32212578
Sci China Life Sci. 2020 Mar;63(3):364-374
pubmed: 32048163
Clin Infect Dis. 2020 Jul 28;71(15):861-862
pubmed: 32201889
Psychol Methods. 2004 Dec;9(4):426-45
pubmed: 15598097
Radiology. 2020 Apr;295(1):22-23
pubmed: 32049600
J Med Virol. 2020 Sep;92(9):1533-1541
pubmed: 32181903
Clin Infect Dis. 2021 Dec 6;73(11):e4208-e4213
pubmed: 32173725
Radiology. 2020 Aug;296(2):E32-E40
pubmed: 32101510
Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jun 24;48(6):456-460
pubmed: 32171190
Pediatr Investig. 2020 Mar;4(1):48-50
pubmed: 32328338
Invest Radiol. 2020 Jun;55(6):332-339
pubmed: 32134800
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):638-641
pubmed: 32164400
Allergy. 2020 Jul;75(7):1730-1741
pubmed: 32077115
Clin Chim Acta. 2020 Jun;505:192-193
pubmed: 32220422
Clin Res Cardiol. 2006 Mar;95(3):136-47
pubmed: 16598526
J Microbiol Immunol Infect. 2020 Jun;53(3):485-487
pubmed: 32198005
Chin Med J (Engl). 2020 Jun 5;133(11):1261-1267
pubmed: 32209890
Eur Radiol. 2020 Jun;30(6):3306-3309
pubmed: 32055945
JAMA. 2020 Apr 7;323(13):1313-1314
pubmed: 32058570
Lancet. 2015 Sep 5;386(9997):995-1007
pubmed: 26049252
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Radiology. 2020 Apr;295(1):210-217
pubmed: 32027573
J Infect Dis. 2015 Jul 15;212(2):183-94
pubmed: 25406333
J Infect. 2020 Jun;80(6):e14-e18
pubmed: 32171866
J Thorac Oncol. 2020 May;15(5):700-704
pubmed: 32114094
J Korean Med Sci. 2020 Mar 23;35(11):e124
pubmed: 32193905
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
J Clin Invest. 2013 Mar;123(3):958-65
pubmed: 23454758
Am J Respir Crit Care Med. 2018 Mar 15;197(6):757-767
pubmed: 29161116
J Infect. 2020 Apr;80(4):394-400
pubmed: 32109443
J Med Virol. 2020 Jul;92(7):797-806
pubmed: 32198776
Korean J Radiol. 2020 Apr;21(4):494-500
pubmed: 32100485
Nat Med. 2020 Apr;26(4):502-505
pubmed: 32284613
An Acad Bras Cienc. 2017 Jan-Mar;89(1):285-299
pubmed: 28423084
Lancet Infect Dis. 2020 Jun;20(6):630-631
pubmed: 32240633
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Mar;22(3):215-220
pubmed: 32204756
Zhonghua Gan Zang Bing Za Zhi. 2020 Mar 20;28(3):234-239
pubmed: 32153170
Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1392-9
pubmed: 22460555
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):215-218
pubmed: 32164091
J Formos Med Assoc. 2020 Mar;119(3):747-751
pubmed: 32113824
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Apr 12;43(4):327-331
pubmed: 32118390
Front Public Health. 2020 Apr 29;8:152
pubmed: 32411652
QJM. 2020 Apr 1;113(4):271-272
pubmed: 32073631
Zhonghua Er Ke Za Zhi. 2020 Apr 2;58(4):269-274
pubmed: 32118389
Int J Antimicrob Agents. 2020 Jul;56(1):105949
pubmed: 32205204
Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jun 24;48(6):467-471
pubmed: 32129583
Chin Med J (Engl). 2020 May 5;133(9):1025-1031
pubmed: 32044814
BMC Med Res Methodol. 2017 Jul 17;17(1):107
pubmed: 28716005
Aging (Albany NY). 2020 Jun 5;12(11):10087-10098
pubmed: 32501810
Euro Surveill. 2020 Mar;25(10):
pubmed: 32183930