Risk attitude and personality in people with multiple sclerosis facing the choice of different disease-modifying therapy scenarios.
Decision-making
Disease-modifying therapies
Multiple sclerosis
Personality
Risk attitude
Shared decision-making
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Oct 2020
15 Oct 2020
Historique:
received:
13
01
2020
revised:
23
07
2020
accepted:
24
07
2020
pubmed:
9
8
2020
medline:
15
5
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
As available disease-modifying therapies (DMTs) increase, evaluating benefit/risk presents greater difficulties, requiring people with MS (PwMS) to play crucial roles in choosing treatment. Although individual attitude toward risk may predict this evaluation, its relation to personality is little studied in MS literature. To prospectively assess risk attitudes and personality traits of PwMS choosing a DMT. In three Italian MS centers (2012-2015), 420 PwMS completed an ad hoc questionnaire on socio-demographic variables, personality, and standard-gamble questions, to evaluate MS- and DMT-related risks through two hypothetical drug scenarios. We assessed the influence of previously collected socio-demographic/clinical characteristics, and personality factors on risk attitude. Almost half of participants were mainly concerned about progressive multifocal leukoencephalopathy; <25% about relapses. Median acceptable risk of death for both hypothetical drug scenarios was 1:10,000; 19-20% would not take any risk related to DMT. Regression analysis revealed that being male, more educated, and with higher impulsivity/sensation-seeking propensity was significantly associated with a higher risk attitude. Both socio-demographic and personality factors affect risk attitude of PwMS facing different DMT scenarios. These findings could affect the shared decision-making process in selecting best treatment option for PwMS.
Sections du résumé
BACKGROUND
BACKGROUND
As available disease-modifying therapies (DMTs) increase, evaluating benefit/risk presents greater difficulties, requiring people with MS (PwMS) to play crucial roles in choosing treatment. Although individual attitude toward risk may predict this evaluation, its relation to personality is little studied in MS literature.
OBJECTIVE
OBJECTIVE
To prospectively assess risk attitudes and personality traits of PwMS choosing a DMT.
METHODS
METHODS
In three Italian MS centers (2012-2015), 420 PwMS completed an ad hoc questionnaire on socio-demographic variables, personality, and standard-gamble questions, to evaluate MS- and DMT-related risks through two hypothetical drug scenarios. We assessed the influence of previously collected socio-demographic/clinical characteristics, and personality factors on risk attitude.
RESULTS
RESULTS
Almost half of participants were mainly concerned about progressive multifocal leukoencephalopathy; <25% about relapses. Median acceptable risk of death for both hypothetical drug scenarios was 1:10,000; 19-20% would not take any risk related to DMT. Regression analysis revealed that being male, more educated, and with higher impulsivity/sensation-seeking propensity was significantly associated with a higher risk attitude.
CONCLUSIONS
CONCLUSIONS
Both socio-demographic and personality factors affect risk attitude of PwMS facing different DMT scenarios. These findings could affect the shared decision-making process in selecting best treatment option for PwMS.
Identifiants
pubmed: 32763510
pii: S0022-510X(20)30401-9
doi: 10.1016/j.jns.2020.117064
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117064Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.