NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
10
2019
accepted:
22
07
2020
pubmed:
9
8
2020
medline:
3
7
2021
entrez:
9
8
2020
Statut:
epublish
Résumé
Interstitial lung fibroblast activation coupled with extracellular matrix production is a pathological signature of pulmonary fibrosis, and is governed by transforming growth factor (TGF)-β1/Smad signalling. TGF-β1 and oxidative stress cooperate to drive fibrosis. Cells can produce reactive oxygen species through activation and/or induction of NADPH oxidases, such as dual oxidase (DUOX1/2). Since DUOX enzymes, as extracellular hydrogen peroxide (H
Identifiants
pubmed: 32764116
pii: 13993003.01949-2019
doi: 10.1183/13993003.01949-2019
pii:
doi:
Substances chimiques
Transforming Growth Factor beta1
0
Hydrogen Peroxide
BBX060AN9V
Dual Oxidases
EC 1.11.1.-
NADPH Oxidases
EC 1.6.3.-
DUOX1 protein, human
EC 1.6.3.1
Duox1 protein, mouse
EC 1.6.3.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©ERS 2021.
Déclaration de conflit d'intérêts
Conflict of interest: R.A. Louzada has nothing to disclose. Conflict of interest: R. Corre has nothing to disclose. Conflict of interest: R. Ameziane El Hassani has nothing to disclose. Conflict of interest: L. Meziani has nothing to disclose. Conflict of interest: M. Jaillet has nothing to disclose. Conflict of interest: A. Cazes has nothing to disclose. Conflict of interest: B. Crestani reports personal fees for lectures from AstraZeneca, grants, personal fees for advisory board work and non-financial support for meeting attendance from Boehringer Ingelheim and Roche, personal fees for advisory board work and non-financial support for meeting attendance from BMS, personal fees for advisory board work from Sanofi, outside the submitted work. Conflict of interest: E. Deutsch reports grants and personal fees from Roche Genentech, AstraZeneca/Medimmune, Merck Serono and Boehringer, grants from Servier, BMS, MSD and Amazon AWS, personal fees from Amgen and Accuray, outside the submitted work. Conflict of interest: C. Dupuy has nothing to disclose.