Mechanisms Regulating Muscle Protein Synthesis in CKD.

Adult Aged Animals Cell Line DNA, Ribosomal Dioxygenases / genetics Disease Models, Animal Epigenesis, Genetic Female Gene Expression Histone Demethylases / genetics Histones / genetics Humans Interferon-gamma / pharmacology Interleukin-6 / genetics Jumonji Domain-Containing Histone Demethylases / genetics Male Mice Mice, Knockout Middle Aged Muscle Fibers, Skeletal / metabolism Muscle Proteins / genetics NF-kappa B / metabolism Nephrectomy Protein Biosynthesis / genetics RNA, Messenger / metabolism Renal Dialysis Renal Insufficiency, Chronic / complications SKP Cullin F-Box Protein Ligases / genetics Signal Transduction Tripartite Motif Proteins / genetics Tumor Necrosis Factor-alpha / pharmacology Ubiquitin-Protein Ligases / genetics
chronic kidney disease epigenetics muscle wasting protein metabolism protein synthesis ribosomal RNA transcription

Journal

Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836

Informations de publication

Date de publication:
11 2020
Historique:
received: 10 12 2019
accepted: 21 06 2020
pubmed: 9 8 2020
medline: 10 3 2021
entrez: 9 8 2020
Statut: ppublish

Résumé

CKD induces loss of muscle proteins partly by suppressing muscle protein synthesis. Muscles of mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specimens from patients with CKD or those undergoing hemodialysis. Inflammation stimulates NO66 expression and changes in NF- Subtotal nephrectomy created a mouse model of CKD with BUN >80 mg/dl. Crossing NO66 Muscle-specific NO66 knockout in mice blocks CKD-induced loss of muscle mass and improves protein synthesis. NO66 suppression of ribosomal biogenesis CKD suppresses muscle protein synthesis

Sections du résumé

BACKGROUND
CKD induces loss of muscle proteins partly by suppressing muscle protein synthesis. Muscles of mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specimens from patients with CKD or those undergoing hemodialysis. Inflammation stimulates NO66 expression and changes in NF-
METHODS
Subtotal nephrectomy created a mouse model of CKD with BUN >80 mg/dl. Crossing NO66
RESULTS
Muscle-specific NO66 knockout in mice blocks CKD-induced loss of muscle mass and improves protein synthesis. NO66 suppression of ribosomal biogenesis
CONCLUSIONS
CKD suppresses muscle protein synthesis

Identifiants

DOI: 10.1681/ASN.2019121277 PMID: 32764136 PMC: PMC7608956
pubmed: 32764136
pii: ASN.2019121277
doi: 10.1681/ASN.2019121277
pmc: PMC7608956
doi:

Substances chimiques

DNA, Ribosomal 0
Histones 0
IL6 protein, human 0
Interleukin-6 0
Muscle Proteins 0
NF-kappa B 0
RNA, Messenger 0
Tripartite Motif Proteins 0
Tumor Necrosis Factor-alpha 0
histone H3 trimethyl Lys4 0
Interferon-gamma 82115-62-6
Dioxygenases EC 1.13.11.-
Histone Demethylases EC 1.14.11.-
Jumonji Domain-Containing Histone Demethylases EC 1.14.11.-
nucleolar protein 66, mouse EC 1.14.11.-
RIOX1 protein, human EC 1.14.11.27
FBXO32 protein, human EC 2.3.2.27
SKP Cullin F-Box Protein Ligases EC 2.3.2.27
TRIM63 protein, human EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2573-2587

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK037175
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147108
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079638
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

Informations de copyright

Copyright © 2020 by the American Society of Nephrology.

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Auteurs

Liping Zhang (L)

Nephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas lipingz@bcm.edu.

Qin Chen (Q)

Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Zihong Chen (Z)

Nephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas.

Ying Wang (Y)

Nephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas.

Jorge L Gamboa (JL)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Talat Alp Ikizler (TA)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
ORCID: 0000-0002-5717-4218

Giacomo Garibotto (G)

Nephrology Division, Department of Internal Medicine, Genoa University, Scientific Hospitalization and Treatment Institute Policlinico San Martino Hospital, Genoa, Italy.
ORCID: 0000-0001-6432-2429

William E Mitch (WE)

Nephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN ribosomique › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH group donors › Oxidoreductases, (N-demethylating) › Histone Demethylases › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Jumonji Domain-Containing Histone Demethylases › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Cellules › Cellules musculaires › Fibres musculaires squelettiques › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines contractiles › Protéines du muscle › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Néphrectomie › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Thérapeutique › Détoxication par sorption › Dialyse rénale › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › SKP cullin F-box protein ligases › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Mechanisms Regulating Muscle Protein Synthesis in CKD.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Mechanisms Regulating Muscle Protein Synthesis in CKD.