Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle-Income Countries.
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
04
01
2020
accepted:
11
06
2020
pubmed:
9
8
2020
medline:
25
5
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where such conditions are prominent. We pooled individual-level data from nationally representative surveys in LMICs that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs) for the relationship between attained adult height and diabetes using multilevel mixed-effects logistic regression models. We estimated ORs for the pooled sample, major world regions, and individual countries, in addition to stratifying all analyses by sex. We examined heterogeneity by individual-level characteristics. Our sample included 554,122 individuals across 25 population-based surveys. Average height was 161.7 cm (95% CI 161.2-162.3), and the crude prevalence of diabetes was 7.5% (95% CI 6.9-8.2). We found no relationship between adult height and diabetes across LMICs globally or in most world regions. When stratifying our sample by country and sex, we found an inverse association between adult height and diabetes in 5% of analyses (2 out of 50). Results were robust to alternative model specifications. Adult height is not associated with diabetes across LMICs. Environmental factors in early life reflected in attained adult height likely differ from those predisposing individuals for diabetes.
Identifiants
pubmed: 32764150
pii: dc20-0019
doi: 10.2337/dc20-0019
pmc: PMC7646204
doi:
Banques de données
figshare
['10.2337/figshare.12556205']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2403-2410Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK007028
Pays : United States
Organisme : NIDDK NIH HHS
ID : L30 DK122468
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007433
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD098982
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR003143
Pays : United States
Informations de copyright
© 2020 by the American Diabetes Association.
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