Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia.
NK alloreactivity
NK cells
haploidentical hematopoietic stem cell transplantation (HSCT)
human cytomegalovirus (HCMV)
killer Ig-like receptors (KIR)
pediatric acute leukemia
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Aug 2020
05 Aug 2020
Historique:
received:
26
06
2020
revised:
31
07
2020
accepted:
01
08
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
NK cells can exert remarkable graft-versus-leukemia (GvL) effect in HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Here, we dissected the NK-cell repertoire of 80 pediatric acute leukemia patients previously reported to have an excellent clinical outcome after αβT/B-depleted haplo-HSCT. This graft manipulation strategy allows the co-infusion of mature immune cells, mainly NK and γδT cells, and hematopoietic stem cells (HSCs). To promote NK-cell based antileukemia activity, 36/80 patients were transplanted with an NK alloreactive donor, defined according to the KIR/KIR-Ligand mismatch in the graft-versus-host direction. The analysis of the reconstituted NK-cell repertoire in these patients showed relatively high proportions of mature and functional KIR
Identifiants
pubmed: 32764469
pii: cancers12082187
doi: 10.3390/cancers12082187
pmc: PMC7463940
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 16764
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 19920
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 20312
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 21724
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 21147
Organisme : Accelerator Award 2017
ID : INCAR
Organisme : Ministero della Salute
ID : RF-2016-02364388
Organisme : Ministero della Salute
ID : 5xmille 2015 and 2016
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2017WC8499_004
Organisme : Horizon 2020
ID : MSCA-ITN-2017-765104-MATURE-NK
Organisme : Ministero della Salute
ID : RC-2019 IRCCS Ospedale Policlinico San Martino
Organisme : Ministero della Salute
ID : RC-2020 OPBG
Références
Semin Hematol. 2019 Jul;56(3):194-200
pubmed: 31202430
Blood. 2009 Mar 26;113(13):3119-29
pubmed: 18945967
Leukemia. 2007 Apr;21(4):848-51
pubmed: 17268518
J Immunol. 2007 Jul 15;179(2):854-68
pubmed: 17617576
Blood Adv. 2018 Oct 9;2(19):2452-2461
pubmed: 30266820
Blood. 2015 Jun 25;125(26):4103-13
pubmed: 25977584
Blood. 2015 Apr 9;125(15):2349-58
pubmed: 25612623
Blood. 2010 Feb 11;115(6):1166-74
pubmed: 19903900
Leukemia. 2020 Mar;34(3):932-937
pubmed: 31586150
Biol Blood Marrow Transplant. 2010 Apr;16(4):533-42
pubmed: 19961944
Annu Rev Immunol. 2002;20:217-51
pubmed: 11861603
Blood. 2008 Aug 1;112(3):708-10
pubmed: 18502829
Semin Hematol. 2016 Oct;53(4):252-256
pubmed: 27788763
Blood. 2018 Jan 11;131(2):247-262
pubmed: 28986344
Nature. 1998 Feb 19;391(6669):795-9
pubmed: 9486650
Front Immunol. 2019 Nov 27;10:2769
pubmed: 31827475
Bone Marrow Transplant. 2008 Jan;41(2):207-14
pubmed: 18084331
J Exp Med. 2009 Jul 6;206(7):1495-503
pubmed: 19528259
Blood. 2007 Jul 1;110(1):433-40
pubmed: 17371948
Trends Immunol. 2018 Jul;39(7):577-590
pubmed: 29793748
Blood. 2010 Oct 7;116(14):2411-9
pubmed: 20581313
Blood. 2004 Dec 1;104(12):3664-71
pubmed: 15304389
Nature. 2005 Aug 4;436(7051):709-13
pubmed: 16079848
Front Immunol. 2019 May 28;10:1179
pubmed: 31231370
Blood. 2012 Jan 12;119(2):399-410
pubmed: 22096237
Annu Rev Immunol. 1996;14:619-48
pubmed: 8717527
N Engl J Med. 2012 Aug 30;367(9):805-16
pubmed: 22931314
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
J Immunol. 2010 Jul 1;185(1):433-41
pubmed: 20525888
J Leukoc Biol. 2013 Dec;94(6):1123-39
pubmed: 24108703
Blood Adv. 2020 Feb 25;4(4):740-754
pubmed: 32092137
Front Immunol. 2019 May 07;10:909
pubmed: 31134055
Blood. 2014 Dec 18;124(26):3914-23
pubmed: 25359989
Blood. 2014 Oct 23;124(17):2744-7
pubmed: 25115891
JCI Insight. 2019 Jan 24;4(2):
pubmed: 30674718
J Immunol. 2012 Nov 15;189(10):5082-8
pubmed: 23077239
Blood. 2017 Aug 3;130(5):677-685
pubmed: 28588018
Biol Blood Marrow Transplant. 2018 Mar;24(3):549-554
pubmed: 29247781
Blood. 2012 Mar 15;119(11):2665-74
pubmed: 22180440
Immunity. 1997 Dec;7(6):753-63
pubmed: 9430221
Leukemia. 2016 Feb;30(2):456-63
pubmed: 26416461
Blood. 2016 Dec 8;128(23):2616-2623
pubmed: 27697774
J Immunol. 2014 Feb 15;192(4):1471-9
pubmed: 24442432
Immunity. 2006 Aug;25(2):331-42
pubmed: 16901727
Biol Blood Marrow Transplant. 2018 Apr;24(4):789-798
pubmed: 29355721
Blood. 2014 Jul 31;124(5):822-6
pubmed: 24869942
J Immunol. 2016 Feb 1;196(3):1400-11
pubmed: 26746188
Immunity. 2015 Mar 17;42(3):431-42
pubmed: 25786175
Front Immunol. 2013 Feb 01;4:15
pubmed: 23378843
Immunity. 2015 Mar 17;42(3):443-56
pubmed: 25786176
Blood. 2005 Mar 1;105(5):2066-73
pubmed: 15536144
Front Immunol. 2020 Feb 14;11:191
pubmed: 32117310
J Immunol. 2007 Mar 15;178(6):3918-23
pubmed: 17339492
J Immunol. 2008 Mar 15;180(6):3969-79
pubmed: 18322206
Nat Rev Immunol. 2005 Mar;5(3):201-14
pubmed: 15719024
Haematologica. 2016 Mar;101(3):371-81
pubmed: 26659918
Semin Oncol. 2012 Dec;39(6):664-73
pubmed: 23206843
Leukemia. 2019 Jan;33(1):230-239
pubmed: 29907809
Oncoimmunology. 2016 Sep 27;6(2):e1216291
pubmed: 28344861
Bone Marrow Transplant. 2019 Nov;54(11):1847-1858
pubmed: 31089287
J Immunol. 2004 Jan 1;172(1):644-50
pubmed: 14688377
Haematologica. 2014 Jul;99(7):1248-54
pubmed: 24658822
J Clin Med. 2019 Nov 07;8(11):
pubmed: 31703320
J Immunol. 2019 Apr 1;202(7):2141-2152
pubmed: 30787107