Treatment of Bone and Joint Tuberculosis in France: A Multicentre Retrospective Study.
bone and joint tuberculosis
diagnosis
extraspinal tuberculosis
spinal tuberculosis
treatment duration
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
05 Aug 2020
05 Aug 2020
Historique:
received:
08
07
2020
revised:
29
07
2020
accepted:
04
08
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
Nine percent of all cases of tuberculosis are bone and joint tuberculosis (BJTB). BJTB occurs in two main forms: spinal (STB) and extraspinal (ESTB). The aim of this study was to compare STB with ESTB in terms of diagnosis, treatment and outcomes. We collected demographic, clinical, microbiological, treatment duration and outcome data for patients with BJTB in a retrospective multicentre study over a 17-year period. Of the 116 patients included in the study, 69 (59.5%) had STB and 47 (40.5%) had ESTB. The median age was higher in the ESTB group. There were significantly more foreign-born patients in the STB group. The median time for diagnosis was longer for ESTB (6 months) than STB (4 months) ( The management of BJTB remains challenging. An earlier diagnosis should be more effective, reducing the total duration of treatment and leading to better tolerance.
Sections du résumé
BACKGROUND
BACKGROUND
Nine percent of all cases of tuberculosis are bone and joint tuberculosis (BJTB). BJTB occurs in two main forms: spinal (STB) and extraspinal (ESTB). The aim of this study was to compare STB with ESTB in terms of diagnosis, treatment and outcomes.
METHODS
METHODS
We collected demographic, clinical, microbiological, treatment duration and outcome data for patients with BJTB in a retrospective multicentre study over a 17-year period.
RESULTS
RESULTS
Of the 116 patients included in the study, 69 (59.5%) had STB and 47 (40.5%) had ESTB. The median age was higher in the ESTB group. There were significantly more foreign-born patients in the STB group. The median time for diagnosis was longer for ESTB (6 months) than STB (4 months) (
CONCLUSION
CONCLUSIONS
The management of BJTB remains challenging. An earlier diagnosis should be more effective, reducing the total duration of treatment and leading to better tolerance.
Identifiants
pubmed: 32764500
pii: jcm9082529
doi: 10.3390/jcm9082529
pmc: PMC7464673
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Int J Infect Dis. 2015 Jul;36:27-30
pubmed: 26004172
Clin Infect Dis. 2017 Jan 15;64(2):111-115
pubmed: 28052967
PLoS One. 2019 Aug 22;14(8):e0221427
pubmed: 31437232
Int Orthop. 2012 Feb;36(2):245-54
pubmed: 22215363
Microbiol Spectr. 2017 Apr;5(2):
pubmed: 28409551
J Pak Med Assoc. 2012 Dec;62(12):1344-8
pubmed: 23866490
J Bone Joint Surg Br. 2004 Aug;86(6):901-4
pubmed: 15330034
Epidemiol Infect. 2017 Jul;145(10):2152-2160
pubmed: 28516818
Int Orthop. 2012 Feb;36(2):261-9
pubmed: 22038440
J Infect. 2009 Nov;59(5):372-3
pubmed: 19766137
Medicine (Baltimore). 1999 Sep;78(5):309-20
pubmed: 10499072
Bone Joint J. 2014 Oct;96-B(10):1366-9
pubmed: 25274923
Bone Joint J. 2018 Apr 1;100-B(4):425-431
pubmed: 29629596
Ann Intern Med. 1986 Jan;104(1):7-12
pubmed: 3940507
Clin Infect Dis. 2016 Oct 1;63(7):e147-e195
pubmed: 27516382
Eur J Radiol. 2006 Jan;57(1):119-30
pubmed: 16139465
Bone Joint J. 2018 Jan;100-B(1):119-124
pubmed: 29305460
Eur J Intern Med. 2006 Oct;17(6):427-9
pubmed: 16962951
MMWR Recomm Rep. 2003 Jun 20;52(RR-11):1-77
pubmed: 12836625
Euro Surveill. 2013 Mar 21;18(12):
pubmed: 23557943
Clin Infect Dis. 2015 Aug 15;61(4):554-62
pubmed: 25908683
Sci Rep. 2015 Jun 08;5:11084
pubmed: 26053666