Apigenin Attenuates the Allergic Reactions by Competitively Binding to ER With Estradiol.
MAPK signaling pathway
Th1/Th2 balance
allergic disease
apigenin
estrogen receptor
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
04
2020
accepted:
26
06
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
Apigenin (API) is a natural phytoestrogen with properties including anti-inflammatory and other abilities. This study aims to 1) systematically validate that excessive estrogen exacerbates allergic reactions; 2) explore the anti-allergic effects and mechanisms of API. We conduct a survey of college students, indicating that of the 505 effective results, 70 individuals were self-reported allergic and 74.1% of them were women, which proved the gender difference in allergic reactions. BALB/c mice are grouped into the negative control group (N-Ctrl), the OVA-sensitized group (P-Ctrl), the estrogenized OVA-sensitized group (E2), and three treatment groups administrating different dose of API (E2 + API/L/M/H).
Identifiants
pubmed: 32765268
doi: 10.3389/fphar.2020.01046
pmc: PMC7378534
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1046Informations de copyright
Copyright © 2020 Yao, Fan, Han, Sun and Che.
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