Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques.

Animals Antibodies, Monoclonal / administration & dosage Biological Availability Biomarkers Drug Therapy, Combination Humans Immunity / drug effects Immunoglobulin Fc Fragments / immunology Integrins / antagonists & inhibitors Interleukins / administration & dosage Isoantibodies / blood Killer Cells, Natural / drug effects Leukocytes, Mononuclear / immunology Macaca mulatta
IL-21 T- cell homing anti-α4β7 combined immune intervention immune activation macaques rhesus macaques

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 11 12 2019
accepted: 20 05 2020
entrez: 9 8 2020
pubmed: 9 8 2020
medline: 13 4 2021
Statut: epublish

Résumé

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections compromise gut immunological barriers, inducing high levels of inflammation and a severe depletion of intestinal CD4

Identifiants

DOI: 10.3389/fimmu.2020.01275 PMID: 32765488 PMC: PMC7379916
pubmed: 32765488
doi: 10.3389/fimmu.2020.01275
pmc: PMC7379916
doi:

Substances chimiques

Antibodies, Monoclonal 0
Biomarkers 0
Immunoglobulin Fc Fragments 0
Integrins 0
Interleukins 0
Isoantibodies 0
integrin alpha4beta7 0
interleukin-21 MKM3CA6LT1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1275

Subventions

Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129745
Pays : United States
Organisme : NIH HHS
ID : U42 OD011023
Pays : United States

Informations de copyright

Copyright © 2020 Pino, Uppada, Pandey, King, Nguyen, Shim, Rogers, Villinger, Paiardini and Byrareddy.

Références

J Infect Dis. 2016 Oct 1;214 Suppl 2:S44-50
pubmed: 27625430
Sci Transl Med. 2019 Sep 11;11(509):
pubmed: 31488581
Cell. 1993 Jul 16;74(1):185-95
pubmed: 7687523
Traffic. 2012 Apr;13(4):610-25
pubmed: 22222055
Cell Host Microbe. 2016 Apr 13;19(4):529-40
pubmed: 27078070
Science. 2019 Sep 6;365(6457):991
pubmed: 31488679
J Immunol. 2010 Jan 1;184(1):114-26
pubmed: 19949086
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20877-82
pubmed: 19933330
Curr HIV/AIDS Rep. 2017 Jun;14(3):93-100
pubmed: 28434169
Gut. 2018 Jan;67(1):43-52
pubmed: 27802155
Hum Vaccin Immunother. 2019;15(10):2482-2490
pubmed: 30897022
Blood. 2012 Nov 8;120(19):3925-35
pubmed: 22990011
Drug Saf. 2019 May;42(5):617-632
pubmed: 30830573
Blood. 2007 May 1;109(9):3873-80
pubmed: 17192392
Curr Opin HIV AIDS. 2016 Jul;11(4):417-23
pubmed: 27078619
PLoS Pathog. 2013;9(7):e1003471
pubmed: 23853592
Z Gastroenterol. 2019 Jul;57(7):843-851
pubmed: 31288280
Vaccine. 2011 Nov 15;29(49):9229-38
pubmed: 21996099
Frontline Gastroenterol. 2019 Oct;10(4):409-416
pubmed: 31656567
J Immunol. 2007 Jun 15;178(12):7640-8
pubmed: 17548600
Sci Transl Med. 2018 Jan 24;10(425):
pubmed: 29367348
Nat Rev Drug Discov. 2014 May;13(5):379-95
pubmed: 24751819
J Virol. 2011 Mar;85(5):2316-24
pubmed: 21159862
Science. 2019 Sep 6;365(6457):1029-1033
pubmed: 31488689
Gastroenterol Hepatol (N Y). 2019 May;15(5 Suppl 2):1-24
pubmed: 31632213
Science. 2019 Sep 6;365(6457):1025-1029
pubmed: 31488688
Sci Transl Med. 2018 Oct 3;10(461):
pubmed: 30282696
Blood. 2011 Sep 8;118(10):2763-73
pubmed: 21693759
Aliment Pharmacol Ther. 2019 Jul;50(1):40-53
pubmed: 31165509
Immunity. 2018 May 15;48(5):872-895
pubmed: 29768175
Nat Immunol. 2008 Mar;9(3):301-9
pubmed: 18264102
Lancet HIV. 2018 May;5(5):e221-e230
pubmed: 29643011
Mucosal Immunol. 2009 Sep;2(5):439-49
pubmed: 19571800
Immunity. 2017 Oct 17;47(4):776-788.e5
pubmed: 29045906
J Immunol. 2011 Jan 15;186(2):1044-59
pubmed: 21149598
J Transl Med. 2011 Jan 27;9 Suppl 1:S2
pubmed: 21284901
J Immunol. 2018 Jan 15;200(2):810-820
pubmed: 29196458
PLoS Pathog. 2019 May 13;15(5):e1007776
pubmed: 31083697
Science. 2019 Sep 6;365(6457):1033-1036
pubmed: 31488690
J Clin Invest. 2015 Dec;125(12):4497-513
pubmed: 26551680
Nat Med. 2014 Dec;20(12):1397-400
pubmed: 25419708
Science. 2016 Oct 14;354(6309):197-202
pubmed: 27738167
J Cell Sci. 2009 Jan 15;122(Pt 2):165-70
pubmed: 19118208

Auteurs

Maria Pino (M)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.

Srijayaprakash Babu Uppada (SB)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.

Kabita Pandey (K)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.

Colin King (C)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.

Kevin Nguyen (K)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.

Inbo Shim (I)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.

Kenneth Rogers (K)

New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, United States.

Francois Villinger (F)

New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, United States.

Mirko Paiardini (M)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States.

Siddappa N Byrareddy (SN)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, United States.
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Safety and Immunological Evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Safety and Immunological Evaluation of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Safety and Immunological Evaluation of...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Safety and Immunological Evaluation of...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Safety and Immunological Evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Safety and Immunological Evaluation of...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Safety and Immunological Evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fc des immunoglobulines › Safety and Immunological Evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Safety and Immunological Evaluation of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Safety and Immunological Evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Alloanticorps › Safety and Immunological Evaluation of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › Safety and Immunological Evaluation of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Safety and Immunological Evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Safety and Immunological Evaluation of...