Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization.
CRP
DNA
PTX3
complement
factor H protein family
necrotic cell
opsonization
pentraxin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
03
2020
accepted:
22
05
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preventing lysis, and the release of intracellular material, including DNA. The FH-related (FHR) proteins share common ligands with FH, due to their homology with this complement regulator, but they lack the domains that mediate the complement inhibitory activity of FH. Because their roles in complement regulation is controversial and incompletely understood, we studied the interaction of FHR-1 and FHR-5 with DNA and dead cells and investigated whether they influence the regulatory role of FH and the complement activation on DNA and dead cells. FH, FHR-1, and FHR-5 bound to both plasmid DNA and human genomic DNA, where both FHR proteins inhibited FH-DNA interaction. The FH cofactor activity was inhibited by FHR-1 and FHR-5 due to the reduced binding of FH to DNA in the presence of the FHRs. Both FHRs caused increased complement activation on DNA. FHR-1 and FHR-5 bound to late apoptotic and necrotic cells and recruited monomeric C-reactive protein and pentraxin 3, and
Identifiants
pubmed: 32765490
doi: 10.3389/fimmu.2020.01297
pmc: PMC7378360
doi:
Substances chimiques
CFHR1 protein, human
0
CFHR5 protein, human
0
Complement C3b Inactivator Proteins
0
Complement System Proteins
9007-36-7
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1297Informations de copyright
Copyright © 2020 Kárpáti, Papp, Schneider, Hajnal, Cserhalmi, Csincsi, Uzonyi and Józsi.
Références
J Leukoc Biol. 2012 Oct;92(4):841-9
pubmed: 22802447
J Immunol. 2006 Jun 15;176(12):7612-20
pubmed: 16751408
J Biol Chem. 2008 Nov 7;283(45):30451-60
pubmed: 18786923
Cell Death Differ. 2016 May;23(5):903-11
pubmed: 26768663
Front Immunol. 2019 Feb 25;10:240
pubmed: 30858847
J Immunol. 2018 Dec 15;201(12):3497-3502
pubmed: 30455399
Mol Oncol. 2019 Dec;13(12):2531-2553
pubmed: 31365168
Nat Rev Nephrol. 2019 Mar;15(3):129-143
pubmed: 30692664
J Exp Med. 2005 Jun 20;201(12):1937-48
pubmed: 15967823
Proc Natl Acad Sci U S A. 2020 May 5;117(18):9942-9951
pubmed: 32321835
J Immunol. 1999 Oct 1;163(7):3957-62
pubmed: 10490997
Front Immunol. 2017 Sep 19;8:1145
pubmed: 28974948
Immunol Rev. 2016 Nov;274(1):218-232
pubmed: 27782329
Kidney Int. 2009 May;75(9):952-60
pubmed: 19177158
Trends Immunol. 2003 Mar;24(3):148-54
pubmed: 12615211
J Immunol. 2018 Apr 1;200(7):2280-2290
pubmed: 29483359
J Am Soc Nephrol. 2016 May;27(5):1413-25
pubmed: 26432903
Am J Kidney Dis. 2012 Jul;60(1):121-5
pubmed: 22503529
Semin Immunol. 2019 Oct;45:101341
pubmed: 31757608
Cell Death Differ. 2009 Dec;16(12):1630-40
pubmed: 19680263
J Clin Invest. 2013 Jun;123(6):2434-46
pubmed: 23728178
Kidney Int. 2010 Oct;78(8):782-8
pubmed: 20703214
J Biol Chem. 2015 Apr 10;290(15):9500-10
pubmed: 25659429
Elife. 2014 Dec 23;3:
pubmed: 25534642
Clin Exp Immunol. 2006 May;144(2):342-52
pubmed: 16634809
Arthritis Rheum. 1998 Jul;41(7):1241-50
pubmed: 9663482
J Immunol. 2015 May 15;194(10):4963-73
pubmed: 25855355
Curr Rheumatol Rep. 2004 Dec;6(6):401-7
pubmed: 15527698
Annu Rev Immunol. 2010;28:131-55
pubmed: 19947883
Science. 1954 Aug 20;120(3112):279-85
pubmed: 13186838
Immunol Rev. 2016 Nov;274(1):172-190
pubmed: 27782331
PLoS One. 2011;6(8):e23991
pubmed: 21915248
J Exp Med. 1998 Dec 21;188(12):2313-20
pubmed: 9858517
J Biol Chem. 2001 Mar 2;276(9):6747-54
pubmed: 11058592
Annu Rev Immunol. 2010;28:157-83
pubmed: 19968561
J Immunol. 2010 Jan 15;184(2):912-21
pubmed: 20008295
Front Immunol. 2017 Jan 13;7:671
pubmed: 28133459
Cell Mol Life Sci. 2002 Aug;59(8):1358-65
pubmed: 12363038
Front Immunol. 2017 May 18;8:571
pubmed: 28572805
Cell Tissue Res. 2011 Jan;343(1):237-49
pubmed: 20683616
J Immunol. 2012 Aug 15;189(4):1858-67
pubmed: 22786770
J Exp Med. 2000 Nov 6;192(9):1353-64
pubmed: 11067883
J Am Soc Nephrol. 2004 Mar;15(3):787-95
pubmed: 14978182
Immunopharmacology. 1999 May;42(1-3):23-30
pubmed: 10408362
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9023-8
pubmed: 18579773
J Biol Chem. 2010 Feb 5;285(6):3766-76
pubmed: 19951950
J Leukoc Biol. 2006 May;79(5):896-903
pubmed: 16641135
J Immunol. 2005 May 15;174(10):6250-6
pubmed: 15879123
Blood. 2009 Sep 17;114(12):2439-47
pubmed: 19528535
J Inflamm (Lond). 2005 May 31;2:5
pubmed: 15927062
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Front Immunol. 2018 Jul 12;9:1607
pubmed: 30050540
FEBS Lett. 1999 Dec 3;462(3):345-52
pubmed: 10622723
Immunol Rev. 2016 Nov;274(1):191-201
pubmed: 27782332
Kidney Int. 2017 Oct;92(4):953-963
pubmed: 28637589
Mol Vis. 2013;19:303-10
pubmed: 23401658
J Immunol. 2008 Jun 1;180(11):7613-21
pubmed: 18490764
Hum Mol Genet. 2010 Dec 1;19(23):4694-704
pubmed: 20843825
J Immunol. 2007 Mar 15;178(6):3831-6
pubmed: 17339482
Autoimmunity. 2011 Aug;44(5):349-56
pubmed: 21231891
Front Immunol. 2019 Aug 02;10:1750
pubmed: 31428091
J Exp Med. 2001 Sep 17;194(6):781-95
pubmed: 11560994
J Biol Chem. 2012 Jun 1;287(23):19528-36
pubmed: 22518841
Front Immunol. 2017 Oct 18;8:1328
pubmed: 29093712
Mol Immunol. 2013 Dec 15;56(3):170-80
pubmed: 23830046
Nat Commun. 2019 Jul 4;10(1):2961
pubmed: 31273197
Trends Immunol. 2015 Jun;36(6):374-84
pubmed: 25979655
PLoS One. 2013 Nov 18;8(11):e78617
pubmed: 24260121
J Biol Chem. 2007 Apr 13;282(15):10894-900
pubmed: 17293598
J Immunol. 2008 Dec 15;181(12):8433-40
pubmed: 19050261
J Clin Immunol. 2008 Jan;28(1):1-13
pubmed: 17828584
Gene. 1995 Sep 11;162(2):225-9
pubmed: 7557433
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90
pubmed: 23487775
J Immunol. 2017 Jul 1;199(1):292-303
pubmed: 28533443
Mol Immunol. 2009 Jan;46(3):335-44
pubmed: 19084272
J Biol Chem. 2007 Sep 28;282(39):28540-8
pubmed: 17699521
Mol Immunol. 2010 Mar;47(6):1347-55
pubmed: 20042240
Nat Immunol. 2010 Sep;11(9):785-97
pubmed: 20720586
Mol Immunol. 2008 Mar;45(5):1199-207
pubmed: 17961651
J Clin Invest. 2014 Jan;124(1):145-55
pubmed: 24334459
Front Immunol. 2018 Jul 23;9:1691
pubmed: 30083158
Kidney Int. 2011 Aug;80(4):397-404
pubmed: 21677636
Mol Immunol. 2016 Apr;72:37-48
pubmed: 26938503